{"id":"W3080413144","doi":"10.1016/j.nbd.2020.105059","title":"Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in","year":2020,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Traumatic Brain Injury and Neurovascular Disturbances","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Health Research; Dr. Ralph and Marian Falk Medical Research Trust; National Institute on Aging","keywords":"Genetically modified mouse; Gene knockin; Neuroinflammation; Traumatic brain injury; Neuroscience; Morris water navigation task; Dementia; Amyloid precursor protein; Transgene; Amyloid (mycology); Disease; Alzheimer's disease; Psychology; Medicine; Cognition; Biology; Internal medicine; Gene; Pathology; Genetics; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003108164,0.0007482786,0.0007847793,0.0006764577,0.0001752708,0.0004545048,0.0003014811,0.000394281,0.0009674435],"category_scores_gemma":[0.0001741185,0.0003741702,0.0006059284,0.0002130465,0.0004326791,0.0002665976,0.0005903055,0.0008445418,0.0002688256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114424,"about_ca_system_score_gemma":0.0002395114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004981765,"about_ca_topic_score_gemma":0.001083203,"domain_scores_codex":[0.9996141,0.00006908042,0.00004442448,0.00007136822,0.00008879598,0.00011229],"domain_scores_gemma":[0.9996461,0.00003507916,0.0001453519,0.00003473752,0.00001817139,0.0001206321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005496471,0.0001172631,0.0004253016,0.00003389531,0.00001981447,0.0002038865,0.00002018769,0.00005122693,0.9978248,0.00006291094,0.00002789386,0.0006630939],"study_design_scores_gemma":[0.000104479,0.004803802,0.03923862,0.00003528567,0.000197364,0.002205939,0.0001794061,0.001730804,0.9494434,0.0002255365,0.001797884,0.00003737883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974176,0.000687404,0.001100791,0.00007545376,0.00002251943,0.00001964545,0.0001373577,0.00007503798,0.0004643438],"genre_scores_gemma":[0.9962172,0.000843488,0.001359406,0.00008026171,0.00001628826,0.00005931847,0.0001635114,0.00002953345,0.001230977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009674435,"threshold_uncertainty_score":0.003236413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02646291055944633,"score_gpt":0.2684099402057107,"score_spread":0.2419470296462644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}