{"id":"W3080448602","doi":"10.1126/sciadv.abb9853","title":"Anti-α <sub>4</sub> β <sub>7</sub> monoclonal antibody–conjugated nanoparticles block integrin α <sub>4</sub> β <sub>7</sub> on intravaginal T cells in rhesus macaques","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Monoclonal antibody; Conjugated system; Block (permutation group theory); Antibody; Integrin; Nanoparticle; Monoclonal; Chemistry; Virology; Molecular biology; Immunology; Biology; Materials science; Biochemistry; Receptor; Nanotechnology; Mathematics; Polymer; Combinatorics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.002217412,0.001474783,0.001854608,0.00166159,0.0009066387,0.0006124274,0.00215219,0.0004879248,0.0000451175],"category_scores_gemma":[0.001889563,0.001357243,0.000410939,0.006482802,0.003818827,0.002068182,0.001049141,0.002565854,0.00144726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007634881,"about_ca_system_score_gemma":0.001863802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006002534,"about_ca_topic_score_gemma":0.0002128717,"domain_scores_codex":[0.9858946,0.0006103932,0.002036191,0.003556547,0.004335559,0.003566768],"domain_scores_gemma":[0.9938381,0.0007664227,0.0007026991,0.001504871,0.001019687,0.002168214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001035848,0.0007782684,0.00461837,0.0003366477,0.00006221567,0.001279828,0.0008114202,0.001165323,0.8863858,0.0001235985,0.000452805,0.1029499],"study_design_scores_gemma":[0.002917648,0.002378762,0.01713837,0.000929317,0.00009587294,0.000184051,0.0009164672,0.004201369,0.9687164,0.000393571,0.0007661684,0.001362043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99054,0.001721142,0.0001885029,0.003570055,0.0008075701,0.001991684,0.0001105026,0.0005261713,0.0005443196],"genre_scores_gemma":[0.9920195,0.004355738,0.0006946938,0.001920164,0.0005586698,0.0001484801,0.00009370691,0.0001956978,0.0000134033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015878,"threshold_uncertainty_score":0.9998001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861664546443786,"score_gpt":0.2996561730277916,"score_spread":0.2810395275633538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}