{"id":"W3080448602","doi":"10.1126/sciadv.abb9853","title":"Anti-α <sub>4</sub> β <sub>7</sub> monoclonal antibody–conjugated nanoparticles block integrin α <sub>4</sub> β <sub>7</sub> on intravaginal T cells in rhesus macaques","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Monoclonal antibody; Conjugated system; Block (permutation group theory); Antibody; Integrin; Nanoparticle; Monoclonal; Chemistry; Virology; Molecular biology; Immunology; Biology; Materials science; Biochemistry; Receptor; Nanotechnology; Mathematics; Polymer; Combinatorics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287272,0.0002543321,0.000169408,0.0002263988,0.0001991518,0.0002417324,0.0002392109,0.0005351316,0.002158254],"category_scores_gemma":[0.0001419731,0.0001984766,0.0002578353,0.00007003013,0.000225356,0.0001819654,0.0001430181,0.0005090003,0.0005327105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864791,"about_ca_system_score_gemma":0.0001969456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968459,"about_ca_topic_score_gemma":0.003198876,"domain_scores_codex":[0.9998649,0.00001864006,0.000007186891,0.0000317037,0.00003396986,0.00004359583],"domain_scores_gemma":[0.9999126,0.0000238151,0.00002093956,0.000008306908,0.00002081731,0.00001342647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004984298,0.00001850693,0.0001363626,0.00001986074,0.000005570447,0.00003956076,0.00001532945,0.00002780139,0.9984415,0.00009454639,0.0001167251,0.001034312],"study_design_scores_gemma":[0.00002033569,0.0005003434,0.004684842,0.00001739291,0.00005824742,0.0004848468,0.00009222468,0.00113914,0.9870197,0.000100873,0.005876515,0.000005587075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869218,0.002745724,0.00410031,0.0002906647,0.00009586055,0.00004295567,0.0001604647,0.00009790536,0.005544236],"genre_scores_gemma":[0.9819696,0.001782332,0.005761956,0.0003282522,0.00003199415,0.00008794446,0.0003213349,0.00004185846,0.009674768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002158254,"threshold_uncertainty_score":0.007220089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861664546443786,"score_gpt":0.2996561730277916,"score_spread":0.2810395275633538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}