{"id":"W3080541733","doi":"10.1101/2020.08.20.260471","title":"Intracellular <i>Staphylococcus aureus</i> perturbs the host cell Ca <sup>2+</sup> -homeostasis to promote cell death","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; University of Alberta","keywords":"Intracellular; Extracellular; Intracellular parasite; Biology; Cell biology; Programmed cell death; Staphylococcus aureus; Microbiology; Cytosol; Apoptosis; Bacteria; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113245,0.0003638979,0.0003016016,0.0001386897,0.00010866,0.0002404461,0.0001195788,0.0002724285,0.0009099529],"category_scores_gemma":[0.00009212346,0.00008020685,0.0002235122,0.00008142423,0.000222086,0.0001360122,0.0001865,0.0003992679,0.0002807822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001904088,"about_ca_system_score_gemma":0.0001718124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003712693,"about_ca_topic_score_gemma":0.0003903909,"domain_scores_codex":[0.9998575,0.00002455346,0.0000169261,0.00002215142,0.00003956826,0.0000392911],"domain_scores_gemma":[0.9999114,0.00001560705,0.00002860284,0.00001178913,0.00001500324,0.00001757786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005065679,0.00001136238,0.00011333,0.00002436311,0.000002188716,0.00004587287,0.000003029909,0.00002224107,0.9993573,0.00003018368,0.00003012545,0.0003094121],"study_design_scores_gemma":[0.00001273412,0.0002805805,0.004633022,0.00001116982,0.0000118265,0.0003006497,0.00003678128,0.00122033,0.9923232,0.00007752098,0.001088662,0.000003577219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989971,0.002607167,0.004343722,0.0003305739,0.00009462777,0.00003020525,0.0004650787,0.0001604722,0.00199711],"genre_scores_gemma":[0.9967456,0.0005171481,0.001545851,0.0001363163,0.00001534127,0.00001893872,0.0002358667,0.00001335205,0.0007716718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009099529,"threshold_uncertainty_score":0.003044128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430660227125923,"score_gpt":0.224126233677089,"score_spread":0.2098196314058298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}