{"id":"W3080555681","doi":"10.1101/2020.08.19.20178368","title":"Inhaled corticosteroids downregulate SARS-CoV-2-related gene expression in COPD: results from a RCT","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care; St. Paul's Hospital; University of British Columbia","funders":"AstraZeneca","keywords":"Formoterol; COPD; Budesonide; Medicine; Fluticasone; Fluticasone propionate; Randomized controlled trial; Formoterol Fumarate; Immunology; Internal medicine; Pharmacology; Corticosteroid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004650466,0.001210032,0.003498481,0.0003482206,0.0004561982,0.001388002,0.000430971,0.002062141,0.004660371],"category_scores_gemma":[0.007531207,0.0004340266,0.006085873,0.0006211536,0.000957278,0.0007599203,0.0005630087,0.001600602,0.0006312624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006791733,"about_ca_system_score_gemma":0.0009097071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057391,"about_ca_topic_score_gemma":0.001669791,"domain_scores_codex":[0.9959201,0.002370503,0.0006690611,0.0004699305,0.0003273921,0.0002430889],"domain_scores_gemma":[0.9949314,0.002693999,0.001137034,0.0004181455,0.0005619616,0.0002574711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8012513,0.005981949,0.01435984,0.03962304,0.06646994,0.0002568766,0.0005013912,0.0004069768,0.01063754,0.0002741744,0.001869005,0.058368],"study_design_scores_gemma":[0.6653022,0.1135712,0.07104329,0.005708666,0.1311345,0.0002474937,0.0004781293,0.0004008655,0.002461986,0.0007942044,0.008757849,0.00009971302],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8310878,0.1517806,0.001414085,0.002216235,0.001911288,0.005829145,0.002106506,0.00008829056,0.003566042],"genre_scores_gemma":[0.9628538,0.02607334,0.001552946,0.002302255,0.001124739,0.003815716,0.0008883612,0.00002488023,0.001363942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004660371,"threshold_uncertainty_score":0.02459425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09248440773629751,"score_gpt":0.4031168632756071,"score_spread":0.3106324555393096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}