{"id":"W3080596815","doi":"10.1038/s41467-020-18096-2","title":"Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":464,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"SLAC National Accelerator Laboratory; Basic Energy Sciences; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; Canadian Institutes of Health Research; Alberta Innovates; U.S. Department of Energy","keywords":"Feline infectious peritonitis; Protease; Coronavirus; Virology; Prodrug; Coronaviridae; Viral replication; Virus; Antiviral drug; Chemistry; Drug; Biology; Enzyme; Medicine; Pharmacology; Coronavirus disease 2019 (COVID-19); Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005575118,0.0001420105,0.000235595,0.00007479476,0.0002379,0.00002616107,0.0007668348,0.0001932492,0.000003179431],"category_scores_gemma":[0.001296256,0.0001050151,0.00007753514,0.0005934295,0.0003567492,0.00006985149,0.0005177462,0.001375078,0.00001836112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000514793,"about_ca_system_score_gemma":0.0002325623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002279013,"about_ca_topic_score_gemma":0.0004121551,"domain_scores_codex":[0.9986389,0.0001944041,0.0003457632,0.0003010137,0.0003429865,0.0001768772],"domain_scores_gemma":[0.9966119,0.0003437204,0.0001479584,0.002540846,0.0003118854,0.00004370115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002391191,0.0002510602,0.00559982,0.00007394799,0.00005941962,0.000003117315,0.001172771,1.513387e-7,0.9739708,0.001992568,0.008777322,0.007859957],"study_design_scores_gemma":[0.0008845201,0.00009306648,0.003526221,0.00007476548,0.00007094055,0.00002627519,0.0001754387,0.001381503,0.6071661,0.000240641,0.3862501,0.0001104622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.909975,0.01432078,0.00006943255,0.07106151,0.00002734088,0.001679863,0.00009025569,0.0001013495,0.002674497],"genre_scores_gemma":[0.933933,0.000192196,0.001110275,0.06444607,0.00007869932,0.0001569576,0.00003799368,0.00002256332,0.00002230719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3774728,"threshold_uncertainty_score":0.5974106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09387567808446048,"score_gpt":0.4051732629586353,"score_spread":0.3112975848741748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}