{"id":"W3080596891","doi":"10.1200/jco.2009.27.15_suppl.1041","title":"Developing a prediction model for benefit from fulvestrant in heavily pretreated metastatic breast cancer (MBC) patients","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency","funders":"","keywords":"Fulvestrant; Medicine; Metastatic breast cancer; Chemotherapy; Internal medicine; Oncology; Tamoxifen; Percentile; Breast cancer; Cancer; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007317484,0.0001641205,0.001279008,0.0001440128,0.00002972523,0.000006029694,0.0001148844,0.0002094356,0.00002415308],"category_scores_gemma":[0.0004565865,0.0001232515,0.0002688209,0.0001562785,0.00006845236,0.0002269276,0.00001146405,0.0005407732,0.000001026556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006755176,"about_ca_system_score_gemma":0.001556739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005595122,"about_ca_topic_score_gemma":0.0001226387,"domain_scores_codex":[0.9969813,0.00009278107,0.002140437,0.0002250564,0.0002905382,0.0002699327],"domain_scores_gemma":[0.9972381,0.000612477,0.001173004,0.0001234561,0.0006252442,0.000227733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0228127,0.002289455,0.139367,0.000035439,0.0004936137,0.00006827121,0.0003900869,0.006708931,0.0003828643,0.0001178733,0.0000933041,0.8272405],"study_design_scores_gemma":[0.02139717,0.005401993,0.943196,0.0004891083,0.0004098852,0.00008244008,0.00005619927,0.01793747,0.00007856972,0.01009221,0.0007355926,0.0001233555],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622804,0.0004492493,0.02712101,0.008887459,0.0005601488,0.0004516423,0.000200808,0.00001488665,0.00003439509],"genre_scores_gemma":[0.9459931,0.0003492714,0.0502464,0.002830545,0.0004862279,0.00001802806,0.0000217384,0.00001865514,0.00003598418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8271171,"threshold_uncertainty_score":0.5026051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1418123278353056,"score_gpt":0.4713859348484983,"score_spread":0.3295736070131927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}