{"id":"W3080632072","doi":"10.1038/s41467-020-17876-0","title":"A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":356,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"European Regional Development Fund; Medical Research Council; Cardiff University; University of Oxford; Parkinson's UK; UK Dementia Research Institute; Alzheimer Society; National Institute for Health and Care Research; NIHR Oxford Biomedical Research Centre; Wellcome Trust; Alzheimer's Society; Llywodraeth Cymru","keywords":"Substantia nigra; Oligodendrocyte; Biology; Neuroscience; Transcriptome; Neuroinflammation; Parkinson's disease; Genome-wide association study; Human brain; Microglia; Cell type; White matter; Gene expression; Genetics; Gene; Disease; Dopaminergic; Cell; Dopamine; Medicine; Pathology; Immunology; Central nervous system; Single-nucleotide polymorphism; Myelin; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125898,0.0001844855,0.0001928854,0.00005533168,0.0006370965,0.00006428337,0.001712889,0.0001757618,0.0000388802],"category_scores_gemma":[0.0004664884,0.000132621,0.0001137672,0.001012795,0.0002621016,0.0001106769,0.0003222504,0.001132329,0.00001574945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001313665,"about_ca_system_score_gemma":0.00003324293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.713092e-7,"about_ca_topic_score_gemma":0.0000344756,"domain_scores_codex":[0.9977597,0.0008841081,0.0003689934,0.000378208,0.0004079814,0.0002010025],"domain_scores_gemma":[0.9974832,0.000571959,0.0003868607,0.001362761,0.0001001314,0.00009511547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001226302,0.0002701269,0.0008168428,0.00000501896,0.000001609308,0.000001567609,0.0002815493,0.00005290985,0.9753762,0.02080207,0.002351316,0.00002849522],"study_design_scores_gemma":[0.0008052409,0.0003435799,0.005183224,0.00001476204,0.00002493096,0.000003613436,0.00004448512,0.0008878424,0.9784017,0.0007177081,0.01332608,0.0002468852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814205,0.0002216821,0.0001056733,0.01207231,0.0001044603,0.0005518048,0.00006269894,0.0001890165,0.005271894],"genre_scores_gemma":[0.9956293,0.0001784835,0.0002527559,0.003730724,0.00001835494,0.00002084915,0.00002307109,0.00003035046,0.0001160937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02008436,"threshold_uncertainty_score":0.5408128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0659487890716034,"score_gpt":0.2504359035151315,"score_spread":0.1844871144435281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}