{"id":"W3080635855","doi":"10.1136/bmj.m2812","title":"Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study","year":2020,"lang":"en","type":"article","venue":"BMJ","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University of Toronto","funders":"National Institute on Aging","keywords":"Hazard ratio; Medicine; Canagliflozin; Amputation; Confidence interval; Internal medicine; Cohort; Cohort study; Rate ratio; Propensity score matching; Population; Proportional hazards model; Lower risk; Surgery; Physical therapy; Diabetes mellitus; Endocrinology; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003355862,0.0005745386,0.001240229,0.001705408,0.0003906048,0.001374605,0.001001592,0.0007340379,0.001325825],"category_scores_gemma":[0.01117259,0.0006108211,0.003498458,0.004551144,0.0002127765,0.0006403936,0.00102042,0.0006892029,0.0002145481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006872581,"about_ca_system_score_gemma":0.00107317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02768091,"about_ca_topic_score_gemma":0.02809914,"domain_scores_codex":[0.9961299,0.001268161,0.0006173398,0.001072106,0.0006610531,0.0002513568],"domain_scores_gemma":[0.9917995,0.001924567,0.003813688,0.001315085,0.0007539238,0.0003932309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00303826,0.0001155169,0.9867734,0.0001922288,0.006714007,0.00006073735,0.00006118804,0.0002105255,0.0001217073,0.00004797829,0.0007195093,0.00194497],"study_design_scores_gemma":[0.001029367,0.0002582213,0.9902108,0.00008854926,0.005670724,0.0002824061,0.00013713,0.001379431,0.0001425645,0.00007589094,0.0006953341,0.00002950678],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823847,0.001739483,0.0005721663,0.000109834,0.00002288376,0.0001424957,0.01453963,0.00002121268,0.0004676069],"genre_scores_gemma":[0.9867338,0.0007428716,0.0005631378,0.0001219098,0.00002402111,0.0001779106,0.01145498,0.000007441996,0.0001738165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02768091,"threshold_uncertainty_score":0.05503958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996451373887471,"score_gpt":0.2832902901443605,"score_spread":0.2633257764054858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}