{"id":"W3080643008","doi":"10.1172/jci138728","title":"Vaccine targeting SIVmac251 protease cleavage sites protects macaques against vaginal infection","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"George & Fay Yee Centre for Healthcare Innovation; CenterLine (Canada); Public Health Agency of Canada; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; NIH Office of the Director; Canadian Institutes of Health Research; Public Health Agency of Canada; National Institutes of Health; National Center for Research Resources; Public Health Agency; University of Wisconsin-Madison","keywords":"Protease; Virology; Cleavage (geology); Medicine; Biology; Microbiology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801912,0.0002478524,0.0002889605,0.0002328881,0.0001227926,0.0002226485,0.0001143157,0.0002962357,0.0005698734],"category_scores_gemma":[0.0002874095,0.00007565985,0.0001567761,0.00005604401,0.0002097773,0.000107555,0.000132492,0.000430259,0.0001201997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379437,"about_ca_system_score_gemma":0.0002608501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007463977,"about_ca_topic_score_gemma":0.00126739,"domain_scores_codex":[0.9999092,0.00001679651,0.000005554755,0.00001790958,0.00001755841,0.0000330212],"domain_scores_gemma":[0.9999167,0.00001681711,0.00002003055,0.00001081322,0.00001133998,0.00002430824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003203622,0.0001255483,0.001649986,0.00005412711,0.000013071,0.00005936214,0.00002914088,0.000245358,0.9883747,0.00005479905,0.00009190488,0.008981693],"study_design_scores_gemma":[0.0001607567,0.01136311,0.07895399,0.0001103682,0.0001061627,0.001337094,0.0002416348,0.0100904,0.8890368,0.0005085882,0.008063508,0.000027552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983343,0.0005554975,0.0006765243,0.00006908166,0.0000125416,0.00001750664,0.00004419169,0.00003555999,0.0002547447],"genre_scores_gemma":[0.9973802,0.000408879,0.001195371,0.00009273898,0.00001715614,0.0000196848,0.0001562748,0.000007172901,0.0007225365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007463977,"threshold_uncertainty_score":0.001906455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06407003859074742,"score_gpt":0.349977615511517,"score_spread":0.2859075769207695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}