{"id":"W3080684525","doi":"10.1101/2020.08.25.267237","title":"A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in <i>Hox</i> Clusters","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; NYU Langone Medical Center; Alex's Lemonade Stand Foundation for Childhood Cancer; York University; Howard Hughes Medical Institute","keywords":"CTCF; Zinc finger; Insulator (electricity); Cohesin; Gene; CRISPR","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009435935,0.000283892,0.0002790885,0.0002699698,0.0001831812,0.0002680519,0.000338634,0.0003226244,0.002797208],"category_scores_gemma":[0.0001276114,0.0001397949,0.0002249545,0.0001316221,0.0001696547,0.0000848858,0.0003068536,0.0003963839,0.0009387397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417737,"about_ca_system_score_gemma":0.0001332332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000428462,"about_ca_topic_score_gemma":0.0008768719,"domain_scores_codex":[0.9998915,0.00001001882,0.000007905881,0.00002479119,0.00004928338,0.00001659358],"domain_scores_gemma":[0.9998769,0.00003379142,0.00003267577,0.00001280274,0.0000105139,0.00003339325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005233387,0.000008258323,0.0002194512,0.00001362736,0.000002152269,0.00008836475,0.000003854104,0.00003905458,0.9987062,0.00005328896,0.00009338244,0.0007199449],"study_design_scores_gemma":[0.00001817363,0.00009847459,0.006385031,0.000004370156,0.0000169065,0.0006265066,0.00001859346,0.001007885,0.9885154,0.00004309925,0.00325896,0.000006729857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761454,0.0004766723,0.01568358,0.0004007846,0.00009431971,0.0000714974,0.002971864,0.0008580273,0.003297852],"genre_scores_gemma":[0.9788091,0.0002576202,0.009779408,0.0001743571,0.00001801097,0.000032321,0.00315732,0.0001841241,0.00758774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002797208,"threshold_uncertainty_score":0.009357631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009039195605153882,"score_gpt":0.2119554936637376,"score_spread":0.2029162980585838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}