{"id":"W3080758726","doi":"10.1089/hum.2020.217","title":"Re: “Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy” by Wilson and Flotte","year":2020,"lang":"en","type":"letter","venue":"Human Gene Therapy","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Genetic enhancement; Myopathy; Medicine; Genetics; Biology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004002224,0.001325936,0.002053854,0.0009887128,0.004955349,0.004745526,0.002263097,0.05638968,0.009637283],"category_scores_gemma":[0.02455364,0.0009995954,0.001498449,0.0007401299,0.002502462,0.003692647,0.00156711,0.05053723,0.009689584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004194344,"about_ca_system_score_gemma":0.004669969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008829802,"about_ca_topic_score_gemma":0.02167709,"domain_scores_codex":[0.9963831,0.001071962,0.0003648949,0.000511001,0.001084636,0.0005843888],"domain_scores_gemma":[0.9920621,0.004482361,0.0005128452,0.0002204828,0.001074397,0.001647856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001491484,0.0000345281,0.0002777568,0.00002782527,0.00002506294,0.0008178275,0.00004683835,0.00003925347,0.0001248631,0.000998906,0.9930443,0.004413706],"study_design_scores_gemma":[0.0006507972,0.0001506402,0.001547856,0.0003804186,0.00007490993,0.001583176,0.0003164299,0.0005371131,0.0003583471,0.008611928,0.9856574,0.0001310124],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003335873,0.001900799,0.0001187732,0.9597362,0.03404191,0.00002370293,0.0001023301,0.00004395249,0.003698728],"genre_scores_gemma":[0.002558282,0.0006990919,0.0001261686,0.9526343,0.03580855,0.00005479958,0.00004569429,0.00003267455,0.008040357],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05638968,"threshold_uncertainty_score":0.03223997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377040549344857,"score_gpt":0.2520576062853419,"score_spread":0.2382872007918933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}