{"id":"W3080758726","doi":"10.1089/hum.2020.217","title":"Re: “Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy” by Wilson and Flotte","year":2020,"lang":"en","type":"letter","venue":"Human Gene Therapy","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Genetic enhancement; Myopathy; Medicine; Genetics; Biology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001652006,0.0005372252,0.0006375089,0.000110365,0.00008406422,0.00006116195,0.0003898353,0.0005077957,0.00006355828],"category_scores_gemma":[0.000009911476,0.0004959966,0.0003168118,0.0000826563,0.0001228684,0.000005112554,0.0001201146,0.0004052226,0.000002797803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002519305,"about_ca_system_score_gemma":0.0001130374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007051245,"about_ca_topic_score_gemma":0.00001992291,"domain_scores_codex":[0.9977003,0.0001993716,0.0005424119,0.0008598158,0.0002529109,0.0004451274],"domain_scores_gemma":[0.9988907,0.00001598014,0.0002636173,0.0006612384,0.00006467601,0.0001037739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0115008,0.0002021397,0.0003667379,0.000060976,0.000403824,0.0003789496,0.0003769952,0.000005073332,0.856307,0.000001380794,0.1266386,0.003757521],"study_design_scores_gemma":[0.05107181,0.004025423,0.0004024469,0.00006967419,0.00008250029,0.00002301581,0.00004251333,0.00001448407,0.2657223,0.0004411215,0.6767409,0.001363826],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550197,0.03424945,0.00003841949,0.009206061,0.0002032178,0.0009204008,0.0002957928,0.00001553528,0.00005138787],"genre_scores_gemma":[0.7879894,0.02357432,0.000269156,0.1801245,0.004650867,0.0003141804,0.002458017,0.000244953,0.0003746123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5905847,"threshold_uncertainty_score":0.9997492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377040549344857,"score_gpt":0.2520576062853419,"score_spread":0.2382872007918933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}