{"id":"W3080821783","doi":"10.1016/j.prp.2020.153186","title":"Reassessment of p53 immunohistochemistry thresholds in invasive high grade bladder cancer shows a better correlation with TP53 and FGFR3 mutations","year":2020,"lang":"en","type":"article","venue":"Pathology - Research and Practice","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; St. Michael's Hospital; Health Sciences Centre; University Health Network; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Immunohistochemistry; Cohort; Medicine; Cystectomy; Retrospective cohort study; Tissue microarray; Oncology; Internal medicine; Bladder cancer; Pathology; P53 expression; Cancer; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002143993,0.0003817107,0.0003444028,0.001412026,0.0003611539,0.001107237,0.0003993596,0.0008003848,0.001447243],"category_scores_gemma":[0.005853461,0.0001911045,0.0004400029,0.000591252,0.0003900342,0.000726938,0.0004321692,0.0007224005,0.0006041331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003897005,"about_ca_system_score_gemma":0.0002225863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088635,"about_ca_topic_score_gemma":0.001409162,"domain_scores_codex":[0.9989268,0.0002487767,0.0001423522,0.0002750578,0.0002708017,0.0001362496],"domain_scores_gemma":[0.9961868,0.001572429,0.0007978995,0.000348046,0.0008132054,0.000281554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001302684,0.0001181516,0.8821408,0.0001086671,0.0001455528,0.000692304,0.0005421379,0.0005457439,0.06773934,0.0001865797,0.0008506813,0.04562741],"study_design_scores_gemma":[0.00001018654,0.000583047,0.9679779,0.0000397659,0.0001175463,0.00234516,0.0005414378,0.001828997,0.02411707,0.0003367403,0.002074332,0.00002793024],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993203,0.001813399,0.002455494,0.000300196,0.00007984545,0.00001305288,0.0001555186,0.0001186821,0.001860723],"genre_scores_gemma":[0.9980629,0.0001817085,0.0009912795,0.00007378664,0.00002207586,0.00000771509,0.000127085,0.00002032345,0.0005130788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002143993,"threshold_uncertainty_score":0.01133865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08177981890476275,"score_gpt":0.4140044506842575,"score_spread":0.3322246317794947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}