{"id":"W3080928896","doi":"10.1016/j.biologicals.2020.08.010","title":"SARS-CoV-2 and the safety margins of cell-based biological medicinal products","year":2020,"lang":"en","type":"article","venue":"Biologicals","topic":"Biomedical and Engineering Education","field":"Engineering","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Takeda Canada","keywords":"Biomanufacturing; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Coronavirus disease 2019 (COVID-19); Industrial fermentation; 2019-20 coronavirus outbreak; Virus; Biology; Cell culture; Biotechnology; Medicine; Food science; Fermentation; Infectious disease (medical specialty); Outbreak; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008640223,0.0002864351,0.0001407324,0.0002731054,0.0002408669,0.0007753678,0.0002105034,0.000548565,0.00298031],"category_scores_gemma":[0.001151035,0.0001226118,0.0002105682,0.0001365151,0.0003660386,0.0004059943,0.0004482049,0.0003333999,0.0005620793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002887766,"about_ca_system_score_gemma":0.0003685171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005974866,"about_ca_topic_score_gemma":0.0003238666,"domain_scores_codex":[0.9993204,0.000151193,0.00003186565,0.0000674543,0.0003500286,0.00007916839],"domain_scores_gemma":[0.9992405,0.0001674853,0.0002644361,0.00005314248,0.0002242849,0.00005012043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005693231,0.00007828712,0.003683807,0.0001014306,0.00001555581,0.0001821887,0.0001340131,0.001433175,0.9804959,0.001121599,0.0002266182,0.01195806],"study_design_scores_gemma":[0.00001659431,0.00171298,0.01183181,0.00004362376,0.00002604814,0.0004124856,0.0003457431,0.002238983,0.9741306,0.001106511,0.008119407,0.00001524892],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789807,0.007019168,0.004567497,0.0004882538,0.00008959708,0.00003647516,0.0002398254,0.00004426267,0.008534078],"genre_scores_gemma":[0.9968251,0.0006971405,0.0008686849,0.00009292422,0.00002311938,0.00000942997,0.0001397618,0.000005698512,0.001338139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00298031,"threshold_uncertainty_score":0.009970188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785850765158746,"score_gpt":0.2279350668707741,"score_spread":0.1900765592191866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}