{"id":"W3080951706","doi":"10.1139/cjpp-2020-0012","title":"Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF/eNOS signaling","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"King Khalid University","keywords":"Nicorandil; Enos; Glibenclamide; Nephrotoxicity; Medicine; Endocrinology; Internal medicine; Vascular endothelial growth factor; Pharmacology; Nitric oxide synthase; Kidney; Nitric oxide; Diabetes mellitus; VEGF receptors","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856726,0.0008207274,0.0005139587,0.0006448744,0.0002932185,0.0001977139,0.0003707549,0.0003235682,0.001555429],"category_scores_gemma":[0.0001544165,0.0002869542,0.0004449689,0.0001998251,0.0004910111,0.0003763901,0.0002124242,0.001275916,0.0002446966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995846,"about_ca_system_score_gemma":0.0005213152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127212,"about_ca_topic_score_gemma":0.002722211,"domain_scores_codex":[0.9998203,0.00002213679,0.00001957936,0.00003372496,0.0000442087,0.00006011666],"domain_scores_gemma":[0.9996662,0.00001533242,0.0001019517,0.00003472736,0.00003172492,0.0001500768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002964103,0.0009335948,0.0008812472,0.00008596697,0.0000275452,0.0001241749,0.00003603998,0.0001301639,0.9908375,0.0001258611,0.0001084332,0.003745243],"study_design_scores_gemma":[0.0001980029,0.004967025,0.01098112,0.0000147362,0.00006472231,0.0003021937,0.0000739623,0.001265019,0.9802116,0.00006536887,0.00184185,0.00001448636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973329,0.0006633529,0.0008815464,0.0001328514,0.0000605639,0.00003204593,0.0001371983,0.00009729927,0.0006622392],"genre_scores_gemma":[0.9906731,0.001248024,0.00234212,0.00009265066,0.00004182071,0.00009912645,0.0003996869,0.0000277049,0.005075841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555429,"threshold_uncertainty_score":0.005203485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619081625381984,"score_gpt":0.2951222150228124,"score_spread":0.2789313987689925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}