{"id":"W3080974142","doi":"10.1111/pai.13337","title":"Genome‐wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations","year":2020,"lang":"en","type":"article","venue":"Pediatric Allergy and Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Institute of Environmental Health Sciences; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Ministerio de Ciencia e Innovación; National Institute of General Medical Sciences; Secretaría de Estado de Investigación, Desarrollo e Innovación; Alfred P. Sloan Foundation; American Asthma Foundation; Agencia Estatal de Investigación; National Institute on Minority Health and Health Disparities; Tobacco-Related Disease Research Program; National Heart, Lung, and Blood Institute; Gordon and Betty Moore Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Robert Wood Johnson Foundation","keywords":"Asthma; Medicine; Genome-wide association study; Odds ratio; Expression quantitative trait loci; Locus (genetics); Exacerbation; Quantitative trait locus; DNA methylation; Genetics; Genotype; Gene; Single-nucleotide polymorphism; Immunology; Internal medicine; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008807033,0.0001235166,0.0002594313,0.0001181279,0.0001412163,0.000009966338,0.00005107054,0.0001067636,0.0000548851],"category_scores_gemma":[0.0003778882,0.0001047448,0.00004216586,0.0002942351,0.00002262514,0.00008578627,0.00004246446,0.0001383633,0.000009727865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007394589,"about_ca_system_score_gemma":0.0001134531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003570416,"about_ca_topic_score_gemma":0.0001061184,"domain_scores_codex":[0.999136,0.00004990707,0.000244915,0.0002526262,0.000109216,0.0002073378],"domain_scores_gemma":[0.9994226,0.0001468117,0.0001302944,0.0001051209,0.0001083496,0.00008688182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005556498,0.0005065057,0.996352,0.00002925209,0.000164768,0.00001538307,0.001108887,0.0002069981,0.00009530578,0.00007513095,0.0003846607,0.0005054166],"study_design_scores_gemma":[0.004301968,0.001295979,0.9874318,0.00000405646,0.0001113235,0.000004822008,0.001724319,0.00007303838,6.389419e-7,0.00002719931,0.004899063,0.0001258467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994216,0.001479255,0.001390336,0.001869544,0.00005942886,0.0007658781,0.00003335034,0.00003976133,0.0001464901],"genre_scores_gemma":[0.9980944,0.0001934699,0.0003979231,0.0005387567,0.0002147642,0.00009873388,0.00005958872,0.00001570888,0.0003866309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008920297,"threshold_uncertainty_score":0.4271369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02349710574237451,"score_gpt":0.2573493763253242,"score_spread":0.2338522705829497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}