{"id":"W3081001765","doi":"10.1158/1538-7445.am2020-6362","title":"Abstract 6362: TH1901, a novel curcumin-peptide conjugate for the treatment of Sortilin-positive (SORT1+) cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Theratechnologies (Canada); Université du Québec à Montréal","funders":"","keywords":"Curcumin; Cancer cell; Cancer; Apoptosis; Cancer research; Chemistry; Internalization; Cell; Pharmacology; Cell growth; Biochemistry; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962419,0.0001463336,0.0001843968,0.00002914328,0.0001710986,0.00002194608,0.0003541196,0.0001045295,0.0001800423],"category_scores_gemma":[0.00009493341,0.0001019417,0.0001415577,0.0002438155,0.0004716918,0.000003430367,0.000083061,0.0001251152,0.00001081604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008906028,"about_ca_system_score_gemma":0.0004857495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009041222,"about_ca_topic_score_gemma":0.0003769056,"domain_scores_codex":[0.9985656,0.00002546549,0.0002511687,0.0004488659,0.0003107325,0.000398193],"domain_scores_gemma":[0.9987997,0.0001717858,0.00008305715,0.000364247,0.0003836961,0.0001975019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003795905,0.000200765,0.0003114273,0.00005212119,0.0002078368,9.483724e-7,0.0003489849,0.00004875607,0.9748968,0.0001846335,0.007467906,0.01590023],"study_design_scores_gemma":[0.0008926818,0.0004757926,0.0023941,0.00001945068,0.00003339618,6.267761e-7,0.0001716419,0.0001499767,0.6998931,0.00003712715,0.2958296,0.0001024319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622244,0.009240836,0.00408884,0.01872436,0.000129939,0.00252791,0.00249,0.00001770923,0.000556069],"genre_scores_gemma":[0.9922926,0.003186161,0.000140122,0.0003896701,0.0007591432,0.002467976,0.0001333118,0.00003254294,0.0005984826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2883617,"threshold_uncertainty_score":0.4157062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1043282301127101,"score_gpt":0.4264096768238154,"score_spread":0.3220814467111053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}