{"id":"W3081034663","doi":"10.1186/s40478-020-01013-5","title":"Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; St. Joseph's Hospital; Robarts Clinical Trials; Parkwood Institute; Western University","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Directorate for Biological Sciences; ALS Society of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Alzheimer's Society; Canada Research Chairs","keywords":"Biology; Neurodegeneration; Cell biology; In vivo; Neurotoxicity; Toxicity; Medicine; Internal medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003009877,0.00132014,0.0006285986,0.001255376,0.0002494948,0.0004652707,0.0003293558,0.0008704222,0.001905059],"category_scores_gemma":[0.0001271163,0.0004448288,0.0006978412,0.0003874807,0.0004050109,0.0005926893,0.0002790622,0.00181553,0.0005335746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004308283,"about_ca_system_score_gemma":0.0001957096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004486324,"about_ca_topic_score_gemma":0.0006025201,"domain_scores_codex":[0.9997306,0.00003348479,0.00004294902,0.00007285905,0.00006376953,0.0000563801],"domain_scores_gemma":[0.9996685,0.00001805509,0.000138705,0.00002240748,0.0000274591,0.0001249475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003962501,0.0001707554,0.0002570663,0.00006629276,0.00001955076,0.00008705322,0.00002234686,0.00004054838,0.9981589,0.00005596782,0.00006489359,0.0006604561],"study_design_scores_gemma":[0.000126896,0.003348523,0.01722886,0.00005064631,0.0001373693,0.0008962433,0.00008909922,0.002169891,0.9728477,0.0002182339,0.002861151,0.00002550392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923832,0.002193792,0.002665868,0.0002092517,0.0001120743,0.00007213181,0.001118462,0.0002829345,0.0009623648],"genre_scores_gemma":[0.9863457,0.002263813,0.004020195,0.0001891654,0.00005018933,0.0002142654,0.001348877,0.00007538746,0.005492393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905059,"threshold_uncertainty_score":0.006373048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1505968643886873,"score_gpt":0.3415416191315452,"score_spread":0.190944754742858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}