{"id":"W3081034663","doi":"10.1186/s40478-020-01013-5","title":"Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; St. Joseph's Hospital; Robarts Clinical Trials; Parkwood Institute; Western University","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Directorate for Biological Sciences; ALS Society of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Alzheimer's Society; Canada Research Chairs","keywords":"Biology; Neurodegeneration; Cell biology; In vivo; Neurotoxicity; Toxicity; Medicine; Internal medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139003,0.0001956077,0.0003978726,0.0001338486,0.0001138083,0.00001464373,0.0005498659,0.00005913844,0.00004958544],"category_scores_gemma":[0.0004901433,0.0001713957,0.0001394099,0.0004127498,0.0002890693,0.0001702498,0.000442194,0.000315023,0.00001020613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002518399,"about_ca_system_score_gemma":0.0003331178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009551061,"about_ca_topic_score_gemma":0.000007646012,"domain_scores_codex":[0.9982437,0.0003579409,0.0004936791,0.0003357688,0.0003162455,0.0002526102],"domain_scores_gemma":[0.9973802,0.0001493016,0.0002212484,0.001535218,0.0002172738,0.0004967353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002771115,0.009398961,0.1693851,0.000312848,0.001119918,0.0003275566,0.0008013716,0.0007331634,0.8125851,0.0008073548,0.000080511,0.001676997],"study_design_scores_gemma":[0.004131632,0.0009812396,0.4817977,0.0003172625,0.001284475,0.00000874937,0.000215668,0.05578696,0.4545411,0.0005126235,0.000009853724,0.0004127904],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896633,0.003861285,0.00005459606,0.003783287,0.000004258253,0.001041349,0.001081338,0.00006738098,0.0004431898],"genre_scores_gemma":[0.9951884,0.001296187,0.002638483,0.0003901697,0.000007996176,0.0001812451,0.0002630847,0.0000286137,0.000005816737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3580441,"threshold_uncertainty_score":0.6989314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1505968643886873,"score_gpt":0.3415416191315452,"score_spread":0.190944754742858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}