{"id":"W3081113288","doi":"10.1158/1078-0432.ccr-20-1064","title":"Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of <i>HOXA9</i> and <i>MEIS1</i> Expression","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Gilead Sciences","keywords":"Myeloid leukemia; Induction chemotherapy; Medicine; Chemotherapy; Leukemia; Oncology; Induction therapy; Cancer research; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004208655,0.0002122145,0.0007123469,0.0003353812,0.00006825365,0.00003004543,0.0001937909,0.0003495355,0.00004885844],"category_scores_gemma":[0.001570184,0.0001697841,0.00004377219,0.001485321,0.001074308,0.000206596,0.0001917986,0.002003694,0.000002970295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007294356,"about_ca_system_score_gemma":0.001633173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005668534,"about_ca_topic_score_gemma":0.0001044812,"domain_scores_codex":[0.9953619,0.00150394,0.000779058,0.0008606951,0.0009337056,0.0005606826],"domain_scores_gemma":[0.9971631,0.00143002,0.0001623216,0.0003306423,0.0004816966,0.0004322204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2137273,0.0006765107,0.550188,0.0006540188,0.0001531067,0.0002644396,0.004907669,0.00004920068,0.2007389,0.00002404316,0.003669909,0.02494697],"study_design_scores_gemma":[0.03538067,0.01234748,0.8753924,0.00151031,0.00005481837,0.00002714324,0.001228017,0.003139159,0.06796302,0.000115581,0.002537146,0.0003042876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981443,0.0007232545,0.00005516445,0.01526537,0.00002412532,0.002310928,0.00003470774,0.00002813785,0.0001152681],"genre_scores_gemma":[0.990707,0.007647678,0.0003016061,0.0005662524,0.0001133919,0.000364441,0.0000242954,0.00004710116,0.000228241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3252044,"threshold_uncertainty_score":0.8705165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07628086996969083,"score_gpt":0.4137209110993023,"score_spread":0.3374400411296115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}