{"id":"W3081113288","doi":"10.1158/1078-0432.ccr-20-1064","title":"Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of <i>HOXA9</i> and <i>MEIS1</i> Expression","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Gilead Sciences","keywords":"Myeloid leukemia; Induction chemotherapy; Medicine; Chemotherapy; Leukemia; Oncology; Induction therapy; Cancer research; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005556002,0.0004179123,0.0007243828,0.0002020795,0.0001667523,0.000389351,0.0002833885,0.000313337,0.0007192862],"category_scores_gemma":[0.0004976431,0.0001532047,0.0003227071,0.0002315314,0.0002322599,0.0002286913,0.000143018,0.0007056833,0.0001780065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005179706,"about_ca_system_score_gemma":0.0003733398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00036039,"about_ca_topic_score_gemma":0.001350257,"domain_scores_codex":[0.9997768,0.00008252819,0.00002213485,0.00004634713,0.00003987797,0.00003228363],"domain_scores_gemma":[0.9996784,0.00007422002,0.0001127674,0.00001885091,0.00001833922,0.00009751424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3235622,0.01091938,0.3400657,0.000449632,0.001402353,0.0009383279,0.0003709034,0.007197311,0.1241309,0.0001490944,0.001902844,0.1889113],"study_design_scores_gemma":[0.03094027,0.2649591,0.6398304,0.00007410342,0.001314531,0.002594725,0.0001742965,0.0136724,0.04201699,0.0002000447,0.004149834,0.00007336144],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991291,0.0004041939,0.00007980668,0.00003110815,0.000005576165,0.00004146615,0.00006301487,0.000006708227,0.000239044],"genre_scores_gemma":[0.999266,0.0001605103,0.0001438357,0.00002904969,0.00001188832,0.00003452053,0.0002029978,0.000001732861,0.0001494383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007243828,"threshold_uncertainty_score":0.003758132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07628086996969083,"score_gpt":0.4137209110993023,"score_spread":0.3374400411296115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}