{"id":"W3081130987","doi":"10.7554/elife.54693","title":"Senotherapeutic drugs for human intervertebral disc degeneration and low back pain","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Arthritis Society; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Intervertebral disc; Cell biology; Senescence; Biology; Apoptosis; Ex vivo; Phenotype; In vivo; Cancer research; Pharmacology; Gene; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371692,0.0003010778,0.0003432592,0.0005418556,0.0001704887,0.0002337961,0.0001820051,0.0002603512,0.002663953],"category_scores_gemma":[0.00008474564,0.00008930342,0.0002690656,0.0002396946,0.0002009513,0.0001262987,0.0001767964,0.0005470972,0.0004852393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951063,"about_ca_system_score_gemma":0.0001951189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004189648,"about_ca_topic_score_gemma":0.002069732,"domain_scores_codex":[0.9999326,0.00001349027,0.0000052754,0.00001001113,0.00002042857,0.00001827508],"domain_scores_gemma":[0.9999652,0.000006098871,0.000009592383,0.000003572835,0.000008345078,0.000007241111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001092072,0.0004173456,0.00056848,0.000863403,0.00007085378,0.0002138198,0.00005365883,0.0002659213,0.9193416,0.000945429,0.001016582,0.07515064],"study_design_scores_gemma":[0.0007230901,0.008749065,0.01826571,0.0002710368,0.0002976123,0.002750815,0.0002023564,0.001087302,0.8617365,0.001038603,0.1048453,0.00003266798],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7512939,0.2179489,0.01020162,0.001781514,0.0004003329,0.0003288256,0.001291531,0.0004819511,0.01627149],"genre_scores_gemma":[0.9197236,0.06092203,0.004931242,0.0004276171,0.00007194882,0.0001555009,0.0008508778,0.00002250232,0.01289459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002663953,"threshold_uncertainty_score":0.008911788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04138631564598823,"score_gpt":0.3075445432877505,"score_spread":0.2661582276417623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}