{"id":"W3081130987","doi":"10.7554/elife.54693","title":"Senotherapeutic drugs for human intervertebral disc degeneration and low back pain","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Arthritis Society; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Intervertebral disc; Cell biology; Senescence; Biology; Apoptosis; Ex vivo; Phenotype; In vivo; Cancer research; Pharmacology; Gene; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420007,0.0001071412,0.0002058063,0.00002802315,0.0000483149,0.00001785356,0.00004474764,0.00006094405,0.0003879885],"category_scores_gemma":[0.00007406363,0.00008761248,0.00008816215,0.00004981296,0.00004039879,0.0000654442,0.00002586248,0.00007740063,0.00007546479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001372974,"about_ca_system_score_gemma":0.00001618901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008957734,"about_ca_topic_score_gemma":0.00001104749,"domain_scores_codex":[0.9993082,0.00005095088,0.0001962403,0.0002146479,0.0000809344,0.0001490863],"domain_scores_gemma":[0.9996985,0.000007699223,0.00003782992,0.0001008345,0.00003980814,0.0001153667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003329631,0.0003565308,0.01324828,0.001501428,0.0002676299,0.00002962518,0.005667078,0.000004713948,0.7166979,0.005501645,0.1773867,0.07900554],"study_design_scores_gemma":[0.03215592,0.03282474,0.1882051,0.001223559,0.0006263421,0.0001369095,0.00376931,0.1385693,0.5436366,0.00117763,0.05562337,0.002051308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600495,0.0004338691,0.02229559,0.01534506,0.0001089125,0.000552326,0.00001652787,0.00007137784,0.0011268],"genre_scores_gemma":[0.9679296,0.00001110742,0.001265758,0.02944176,0.0004011244,0.00002695301,0.00009006682,0.00002229246,0.0008113457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1749568,"threshold_uncertainty_score":0.4248202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04138631564598823,"score_gpt":0.3075445432877505,"score_spread":0.2661582276417623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}