{"id":"W3081164002","doi":"10.1165/rcmb.2020-0285le","title":"Azithromycin Downregulates Gene Expression of IL-1β and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2","year":2020,"lang":"en","type":"letter","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Azithromycin; Biology; Inflammation; Gene; TMPRSS2; Downregulation and upregulation; Gene expression; Gene expression profiling; Microarray analysis techniques; Cancer research; Immunology; Medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000064702,0.0001842021,0.0002461944,0.0001616925,0.0001147245,0.0002240066,0.0000796721,0.0001907397,0.001713639],"category_scores_gemma":[0.00008341765,0.00008344399,0.0001986272,0.00011293,0.0001359308,0.00009363467,0.00009635641,0.0003638377,0.0003040362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539823,"about_ca_system_score_gemma":0.0001035691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173914,"about_ca_topic_score_gemma":0.0007777569,"domain_scores_codex":[0.9998817,0.00001597254,0.00001126678,0.00003023439,0.00002910742,0.00003165565],"domain_scores_gemma":[0.9999547,0.00001171734,0.00001008068,0.000005250957,0.000006635059,0.00001157488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001796794,0.00001913762,0.0002595457,0.00002740575,0.000003024802,0.00002350392,0.00000787002,0.00001629057,0.9986249,0.000006845134,0.00002350717,0.0008083335],"study_design_scores_gemma":[0.00004443952,0.00144713,0.05486603,0.00001000833,0.00003606436,0.0004058001,0.0001112187,0.0008456265,0.9392967,0.0000276228,0.00290195,0.000007415166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.9959903,0.001955025,0.0004721465,0.00009930537,0.00002874657,0.00002558307,0.0004430901,0.00003927882,0.000946506],"genre_scores_gemma":[0.9953254,0.0008465608,0.0009622164,0.00007336115,0.00001719565,0.0000447714,0.000702987,0.000007054282,0.002020413],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.001713639,"threshold_uncertainty_score":0.005732656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046102905966416,"score_gpt":0.2663070799986595,"score_spread":0.2458460509389953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}