{"id":"W3081180224","doi":"10.1053/j.gastro.2020.08.037","title":"Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Genentech; Ferring Pharmaceuticals; Kyowa Hakko Kirin; Ipsen Biopharmaceuticals; Biogen; Tillotts Pharma; Boehringer Ingelheim; Atlantic Healthcare; Alnylam Pharmaceuticals; Janssen Pharmaceuticals; Gilead Sciences; Janssen Research and Development; Medtronic; Roche; Takeda Pharmaceutical Company; AbbVie; MedImmune; Merck; Pfizer; Shire; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ustekinumab; Ulcerative colitis; Medicine; Gastroenterology; Internal medicine; Dermatology; Disease; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003168084,0.0001188788,0.0001878246,0.00003277826,0.00002553335,0.000003697749,0.0000455038,0.00006339309,0.000005119319],"category_scores_gemma":[0.00006025322,0.0001044169,0.00001834848,0.00002369848,0.0001505828,0.000003797321,0.00004946291,0.00004900962,8.39099e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002016919,"about_ca_system_score_gemma":0.00002194317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006752196,"about_ca_topic_score_gemma":0.0001157399,"domain_scores_codex":[0.9992096,0.0001619634,0.0001755859,0.0002480729,0.00004490633,0.0001598709],"domain_scores_gemma":[0.9996661,0.00002658692,0.00008522557,0.0001049652,0.00002686915,0.00009026817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003612253,0.00007396267,0.9958658,0.00001795717,0.00003368374,0.00001266418,0.00016646,0.000005349817,0.0000797646,0.00002618589,0.00001298995,0.00009290834],"study_design_scores_gemma":[0.008745697,0.004090998,0.9868849,0.000005741795,0.00003141865,0.000001190665,0.00001986045,0.000004664659,0.0001385253,0.0000131676,0.00001860329,0.00004524058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993568,0.00001378208,0.00005162002,0.0001372929,0.00001293338,0.0003418034,0.00005478434,0.00000471498,0.0000262462],"genre_scores_gemma":[0.9994962,0.000003230286,0.0001738544,0.0001318508,0.00001723735,0.00002064671,0.0001404969,0.000008580981,0.000007957454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008980929,"threshold_uncertainty_score":0.4257997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195464659980255,"score_gpt":0.2219270306847592,"score_spread":0.2099723840849566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}