{"id":"W3081180224","doi":"10.1053/j.gastro.2020.08.037","title":"Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Genentech; Ferring Pharmaceuticals; Kyowa Hakko Kirin; Ipsen Biopharmaceuticals; Biogen; Tillotts Pharma; Boehringer Ingelheim; Atlantic Healthcare; Alnylam Pharmaceuticals; Janssen Pharmaceuticals; Gilead Sciences; Janssen Research and Development; Medtronic; Roche; Takeda Pharmaceutical Company; AbbVie; MedImmune; Merck; Pfizer; Shire; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ustekinumab; Ulcerative colitis; Medicine; Gastroenterology; Internal medicine; Dermatology; Disease; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002784176,0.0002677727,0.000758558,0.0005671235,0.0002046196,0.0005378436,0.0002129517,0.0004050062,0.001185367],"category_scores_gemma":[0.004905783,0.0001796881,0.0004788118,0.0005821491,0.000250047,0.0004576565,0.0002956759,0.0007216498,0.000150192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389439,"about_ca_system_score_gemma":0.0001658056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001886274,"about_ca_topic_score_gemma":0.0004956831,"domain_scores_codex":[0.9983682,0.0007734803,0.0001967375,0.0001742808,0.0003723376,0.0001149978],"domain_scores_gemma":[0.9917892,0.003035452,0.003654651,0.0002748359,0.0005501677,0.0006957425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0055,0.0001632381,0.9807313,0.00005631424,0.0003446829,0.00005762936,0.00002053639,0.0001764752,0.0008341252,0.00001284919,0.00008862626,0.01201407],"study_design_scores_gemma":[0.0002041025,0.002071847,0.9960472,0.00001322089,0.0002454784,0.0002892406,0.00002902529,0.0004712112,0.0003644315,0.00003163003,0.0002259775,0.000006665028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949504,0.003919208,0.0001542173,0.0001104671,0.00001481744,0.00001984815,0.000161294,0.000007774272,0.0006619986],"genre_scores_gemma":[0.9992723,0.0002465044,0.0001261525,0.00004027871,0.00004235593,0.00001053711,0.0001805173,0.000001423578,0.00007995084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002784176,"threshold_uncertainty_score":0.01472431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195464659980255,"score_gpt":0.2219270306847592,"score_spread":0.2099723840849566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}