{"id":"W3081210428","doi":"10.1002/pro.3931","title":"A phage‐displayed single‐chain Fab library optimized for rapid production of single‐chain <scp>IgGs</scp>","year":2020,"lang":"en","type":"article","venue":"Protein Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Single chain; Phage display; Chain (unit); Immunoglobulin light chain; Single-cell analysis; Chemistry; Peptide library; Molecular biology; Computational biology; Biology; Microbiology; Biochemistry; Cell; Antibody; Peptide sequence; Physics; Gene; Genetics; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009309713,0.0002380519,0.0004666637,0.0002372035,0.0002973745,0.00008590493,0.0005166738,0.00008266521,0.00008169638],"category_scores_gemma":[0.003511677,0.0001880829,0.0001740277,0.001467303,0.001065757,0.0005594558,0.0002668832,0.0002499708,0.00002486439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004908414,"about_ca_system_score_gemma":0.0004699937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001642057,"about_ca_topic_score_gemma":6.358506e-7,"domain_scores_codex":[0.9968852,0.0000923841,0.000484118,0.0007846662,0.001078089,0.0006755463],"domain_scores_gemma":[0.9984672,0.000221368,0.0002083929,0.0003437143,0.0002849966,0.0004743463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006846469,0.0003256584,0.0001929154,0.0005504548,0.00002559066,0.00001730563,0.001085928,0.0000419895,0.9826255,0.0004917558,0.001686503,0.0122717],"study_design_scores_gemma":[0.001381446,0.002055999,0.0002648286,0.0002242574,0.00002473797,0.00002827618,0.0003422225,0.00642217,0.9739475,0.0003445632,0.01485869,0.0001052655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626267,0.001290558,0.004607997,0.0214679,0.0002774195,0.00439105,0.00005372698,0.0001832551,0.005101424],"genre_scores_gemma":[0.9419959,0.00004548758,0.04945341,0.0008204752,0.0006060514,0.0002467897,0.00003014115,0.00004175862,0.006759967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04484541,"threshold_uncertainty_score":0.7669799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05489348007235323,"score_gpt":0.2967729476835821,"score_spread":0.2418794676112289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}