{"id":"W3081212059","doi":"10.1007/s10571-020-00942-y","title":"Necroptotic–Apoptotic Regulation in an Endothelin-1 Model of Cerebral Ischemia","year":2020,"lang":"en","type":"article","venue":"Cellular and Molecular Neurobiology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Necroptosis; Programmed cell death; RIPK1; Apoptosis; Cell biology; Biology; TUNEL assay; Caspase 3; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003745774,0.0005694643,0.0005386642,0.0005336124,0.0003543782,0.0003491068,0.0004233739,0.0005943876,0.001085061],"category_scores_gemma":[0.0002309123,0.0001888608,0.0003183317,0.000335022,0.0005865524,0.0004682292,0.0002229046,0.001311508,0.000148391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005988854,"about_ca_system_score_gemma":0.0003329586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006122511,"about_ca_topic_score_gemma":0.0008479519,"domain_scores_codex":[0.9997633,0.00005152144,0.00002170256,0.00003844309,0.00005479859,0.00007021109],"domain_scores_gemma":[0.9998052,0.0000298035,0.0000672152,0.00002563537,0.00002163038,0.00005067635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005840641,0.0005301221,0.0002610175,0.0001095959,0.00002250295,0.0008129267,0.00009766766,0.0003830996,0.9890739,0.0006427619,0.0001238928,0.00210187],"study_design_scores_gemma":[0.000419327,0.003661337,0.007720824,0.00002039271,0.0001036663,0.0009996598,0.0001447219,0.003331047,0.9817155,0.0005184915,0.001339817,0.0000252798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961637,0.001240772,0.001355518,0.0001401182,0.00008414786,0.00004758614,0.0001416942,0.00003532708,0.0007910145],"genre_scores_gemma":[0.9949042,0.001084135,0.001265768,0.00006888016,0.00004919255,0.00009583221,0.000158873,0.000008540324,0.002364579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085061,"threshold_uncertainty_score":0.004345298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328932669685791,"score_gpt":0.2160270236120584,"score_spread":0.2027376969152005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}