{"id":"W3081239366","doi":"10.1177/1078155220951845","title":"Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer","year":2020,"lang":"en","type":"article","venue":"Journal of Oncology Pharmacy Practice","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Capecitabine; Oncology; Internal medicine; Colorectal cancer; Breast cancer; Oxaliplatin; Population; Irinotecan; Bevacizumab; Cohort; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346424,0.0001330762,0.0002881388,0.001033648,0.0001936058,0.0004513038,0.0001754301,0.0002442745,0.0008393003],"category_scores_gemma":[0.001213412,0.0001192443,0.0002051927,0.001381757,0.000176341,0.0001759439,0.0003009573,0.0001896019,0.0001384714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154901,"about_ca_system_score_gemma":0.000219992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002082459,"about_ca_topic_score_gemma":0.002740333,"domain_scores_codex":[0.9997042,0.00006849851,0.00003342801,0.00008946422,0.00005878386,0.00004572737],"domain_scores_gemma":[0.9992037,0.0001382306,0.0004637593,0.00004130584,0.00007388358,0.00007914835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000142844,0.000009101758,0.9966748,0.00001383426,0.0000272771,0.00003801191,0.00001621265,0.00008317218,0.0007370917,0.000009320212,0.00008011332,0.002168247],"study_design_scores_gemma":[0.000004742786,0.00005185174,0.9988816,0.00000297345,0.00002126423,0.0002759307,0.0000363681,0.0001495431,0.0003134121,0.00001393647,0.0002468717,0.000001632673],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982215,0.000482547,0.0001221503,0.00003616438,0.000002389427,0.00001032222,0.0008106292,0.000005137513,0.000309204],"genre_scores_gemma":[0.9988048,0.0001383926,0.000264491,0.00002651877,0.000005664704,0.00001319425,0.0006583955,0.000001496373,0.00008698345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002082459,"threshold_uncertainty_score":0.004140675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02303683409945948,"score_gpt":0.3634960484397493,"score_spread":0.3404592143402898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}