{"id":"W3081257677","doi":"10.1038/s41467-020-18020-8","title":"GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":299,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Ontario Institute for Cancer Research; Hospital for Sick Children; McGill University Health Centre; Structural Genomics Consortium; Princess Margaret Cancer Centre; SickKids Foundation; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Novartis Pharma; Ontario Genomics Institute; Government of Canada; Government of Ontario; Ontario Institute for Cancer Research; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; CIHR Skin Research Training Centre; McGill University Health Centre; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Terry Fox Research Institute; Cancer Research Society; Princess Margaret Cancer Foundation; University of Texas Southwestern Medical Center; Pfizer","keywords":"Triple-negative breast cancer; GLUT1; Cancer research; Breast cancer; Retinoblastoma; Cancer; Glucose transporter; Biology; Medicine; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007380733,0.0001412483,0.000271847,0.0000902782,0.0001250062,0.00001029026,0.0002839436,0.0002983444,0.00009878828],"category_scores_gemma":[0.0002661693,0.0001392691,0.0001129244,0.0007868587,0.0002106857,0.00007810038,0.0002017817,0.001269932,0.00001130007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632442,"about_ca_system_score_gemma":0.0002715813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002854794,"about_ca_topic_score_gemma":0.000246687,"domain_scores_codex":[0.999028,0.0001054227,0.0002725089,0.0002087067,0.000239207,0.000146177],"domain_scores_gemma":[0.9981382,0.0001180506,0.0001796398,0.0007655313,0.0006514689,0.0001471463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002326157,0.001925831,0.01009306,0.0003635768,0.001809562,0.00004915795,0.01479376,0.00008057311,0.810508,0.04498393,0.1023884,0.01067796],"study_design_scores_gemma":[0.01817636,0.001500771,0.1552054,0.002670807,0.002603381,0.0004346602,0.001895959,0.008649176,0.7843983,0.001689913,0.02136587,0.001409492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3662229,0.04760258,0.00198841,0.5152693,0.0008023408,0.005474302,0.006049994,0.0007555118,0.05583469],"genre_scores_gemma":[0.9935858,0.0009812526,0.002026882,0.002894122,0.00009720203,0.00007400339,0.0002687919,0.00002792653,0.00004404373],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6273629,"threshold_uncertainty_score":0.567923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604931034084354,"score_gpt":0.2876299906970129,"score_spread":0.2715806803561694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}