{"id":"W3081257677","doi":"10.1038/s41467-020-18020-8","title":"GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":299,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Ontario Institute for Cancer Research; Hospital for Sick Children; McGill University Health Centre; Structural Genomics Consortium; Princess Margaret Cancer Centre; SickKids Foundation; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Novartis Pharma; Ontario Genomics Institute; Government of Canada; Government of Ontario; Ontario Institute for Cancer Research; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; CIHR Skin Research Training Centre; McGill University Health Centre; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Terry Fox Research Institute; Cancer Research Society; Princess Margaret Cancer Foundation; University of Texas Southwestern Medical Center; Pfizer","keywords":"Triple-negative breast cancer; GLUT1; Cancer research; Breast cancer; Retinoblastoma; Cancer; Glucose transporter; Biology; Medicine; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009490693,0.0002436574,0.0003611324,0.0002331403,0.0001096299,0.0002389387,0.0001711232,0.0001660589,0.001619943],"category_scores_gemma":[0.0001145344,0.00007650661,0.0002003184,0.0001804812,0.0001475745,0.0001022084,0.0001350395,0.0004795636,0.0003508757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258098,"about_ca_system_score_gemma":0.0002151288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035237,"about_ca_topic_score_gemma":0.001965514,"domain_scores_codex":[0.9999453,0.000009599788,0.000004810487,0.000008096516,0.0000143513,0.00001799849],"domain_scores_gemma":[0.9999495,0.0000122149,0.000009960399,0.000007864227,0.000004752722,0.00001565519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001087478,0.000328116,0.000699523,0.00009968281,0.00001804695,0.00008351319,0.00003211263,0.0003272497,0.9857036,0.00009380654,0.0003333584,0.0111934],"study_design_scores_gemma":[0.0001671859,0.005456518,0.02128484,0.00001591473,0.00005507934,0.0005966768,0.00007923472,0.002085551,0.9645438,0.0001147248,0.005591552,0.000009015033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958783,0.001745424,0.0003191877,0.0001155823,0.00002957458,0.00001821457,0.0003155768,0.00009921545,0.00147882],"genre_scores_gemma":[0.9956412,0.001462017,0.0004145463,0.00006174193,0.000007456555,0.00001675149,0.0005917919,0.00002091233,0.00178349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619943,"threshold_uncertainty_score":0.005419195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604931034084354,"score_gpt":0.2876299906970129,"score_spread":0.2715806803561694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}