{"id":"W3081272651","doi":"10.1159/000509393","title":"A Multicentre, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of the S1P Receptor Agonist KRP203 in Patients with Moderately Active Refractory Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Inflammatory Intestinal Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Tolerability; Ulcerative colitis; Agonist; Refractory (planetary science); Medicine; Placebo; Double blind; Internal medicine; Partial agonist; Pharmacology; Gastroenterology; Receptor; Adverse effect; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003603216,0.001366348,0.003541906,0.0005198903,0.0007841584,0.0006518125,0.0008961128,0.00158108,0.003715681],"category_scores_gemma":[0.002022146,0.0007455979,0.001454141,0.0005068562,0.001476813,0.0008462544,0.000477888,0.001797992,0.0007509917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005211614,"about_ca_system_score_gemma":0.001418387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003855349,"about_ca_topic_score_gemma":0.0007201346,"domain_scores_codex":[0.9984962,0.00087089,0.0001168356,0.0002290053,0.0001470705,0.0001399377],"domain_scores_gemma":[0.9984072,0.0002773028,0.0003451994,0.0002087199,0.0001489541,0.0006126621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9385724,0.02434276,0.003263395,0.0006377329,0.0007572717,0.00009340326,0.0001221646,0.0002274346,0.01692953,0.00004294033,0.0003889884,0.0146221],"study_design_scores_gemma":[0.658457,0.3306851,0.009054357,0.00001490255,0.000380032,0.00007311156,0.00002540551,0.0002268072,0.0006643888,0.00002678208,0.0003754811,0.0000165641],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941696,0.001358233,0.0005565041,0.0001716225,0.0001374205,0.002831774,0.0002836101,0.00005131209,0.0004397503],"genre_scores_gemma":[0.9913737,0.0006598611,0.002245545,0.000602541,0.0003118699,0.003506737,0.0005443098,0.00001289913,0.0007424581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003715681,"threshold_uncertainty_score":0.0190559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486406867820378,"score_gpt":0.262554374412365,"score_spread":0.2476903057341612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}