{"id":"W3081302025","doi":"10.1200/jco.2009.27.15_suppl.4082","title":"Phase I study of the IXO regimen, irinotecan (I), capecitabine (X), oxaliplatin (O), as first-line therapy for metastatic colorectal cancer: Final survival results","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; Ottawa Hospital","funders":"","keywords":"Medicine; Irinotecan; Capecitabine; Neutropenia; Oxaliplatin; Internal medicine; Regimen; Gastroenterology; Adverse effect; Toxicity; Phases of clinical research; Colorectal cancer; Febrile neutropenia; Vomiting; Nausea; Mucositis; Rash; Cancer; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001099427,0.001235168,0.001210362,0.0003121289,0.000343329,0.0006228298,0.0005733685,0.00077048,0.00218515],"category_scores_gemma":[0.0005359335,0.0003930531,0.0006904352,0.0002882715,0.0007128219,0.0003764478,0.0002178047,0.001805487,0.0005085025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007525567,"about_ca_system_score_gemma":0.001519224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008942453,"about_ca_topic_score_gemma":0.0016589,"domain_scores_codex":[0.9997411,0.0001112894,0.00001335649,0.00003919487,0.00002764982,0.00006740565],"domain_scores_gemma":[0.9995316,0.00007208093,0.00007829574,0.00003659418,0.00002995602,0.0002515536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5479318,0.1385696,0.01748265,0.001118985,0.0009014533,0.0008298852,0.0006230972,0.005636072,0.165911,0.0004355437,0.006196948,0.1143629],"study_design_scores_gemma":[0.2509071,0.7117134,0.01694168,0.00003936238,0.0004028801,0.0005451498,0.00005207115,0.001915274,0.01434667,0.0001490391,0.002961688,0.0000257247],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958059,0.0009167376,0.0004951467,0.0001611903,0.00004399892,0.001038341,0.000543526,0.00004807142,0.0009470137],"genre_scores_gemma":[0.9904689,0.001240233,0.001686892,0.0003567386,0.0000873683,0.001455711,0.002386927,0.00002727394,0.002289931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218515,"threshold_uncertainty_score":0.007310033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2077172886155965,"score_gpt":0.5094003698731585,"score_spread":0.301683081257562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}