{"id":"W3081311716","doi":"10.1002/ana.25880","title":"Evaluating Lipid‐Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization","year":2020,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Medical Research Council; Vetenskapsrådet; Barts Charity","keywords":"Mendelian randomization; Odds ratio; Drug; Parkinson's disease; Confidence interval; Medicine; Disease; Internal medicine; Apolipoprotein E; Apolipoprotein B; Bioinformatics; Pharmacology; Biology; Cholesterol; Genetics; Genotype; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0473009,0.001395284,0.001892153,0.001539085,0.0004529499,0.0009651162,0.0010199,0.001602579,0.004164464],"category_scores_gemma":[0.0901631,0.0004845238,0.002301648,0.001723957,0.001253031,0.00106561,0.0008606964,0.000638682,0.0002733576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007090025,"about_ca_system_score_gemma":0.001435481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001273313,"about_ca_topic_score_gemma":0.0009008929,"domain_scores_codex":[0.9007276,0.09007766,0.002517032,0.003628333,0.002346741,0.0007027095],"domain_scores_gemma":[0.9457884,0.04352762,0.004756711,0.00481459,0.0007874285,0.0003252848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2117656,0.002876923,0.1869517,0.004713233,0.05895799,0.00498269,0.001424039,0.03675849,0.02949529,0.1400094,0.007755132,0.3143095],"study_design_scores_gemma":[0.08920658,0.07419894,0.1228704,0.0009499693,0.05926567,0.006942118,0.0004269413,0.3221215,0.03584961,0.2498942,0.0376041,0.0006700782],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5666757,0.005108645,0.410219,0.00189984,0.001018112,0.006487699,0.001876273,0.00117286,0.005541943],"genre_scores_gemma":[0.8482528,0.0009347725,0.1448408,0.0008003406,0.0001541419,0.003652376,0.0002974153,0.00009116562,0.0009762327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0473009,"threshold_uncertainty_score":0.2501541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06958603172181384,"score_gpt":0.3555966298920235,"score_spread":0.2860105981702096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}