{"id":"W3081331636","doi":"10.1200/jco.2009.27.15_suppl.4130","title":"A phase Ib/II trial of AMG 655 and panitumumab (pmab) for the treatment (tx) of metastatic colorectal cancer (mCRC): Safety results","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Irinotecan; Clinical endpoint; Internal medicine; Panitumumab; Colorectal cancer; Pharmacokinetics; Oxaliplatin; Response Evaluation Criteria in Solid Tumors; Phases of clinical research; Adverse effect; Oncology; Nausea; Cancer; Gastroenterology; Clinical trial; Cetuximab","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002458708,0.001960712,0.002148206,0.0004454947,0.0004200817,0.001229185,0.0008326001,0.001467214,0.004860018],"category_scores_gemma":[0.001013521,0.0007035194,0.001376275,0.0004605874,0.0009630146,0.001016054,0.0004830684,0.003323977,0.001375444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072477,"about_ca_system_score_gemma":0.002020587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001736989,"about_ca_topic_score_gemma":0.003618374,"domain_scores_codex":[0.999411,0.0002677226,0.00002917955,0.00009720658,0.00006236618,0.0001325653],"domain_scores_gemma":[0.9989232,0.0001457657,0.0001621639,0.00007472903,0.00005018495,0.0006439462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8793126,0.04094386,0.003657063,0.000510923,0.0008683508,0.0002198869,0.0001643102,0.001177818,0.01597458,0.0002175274,0.004095584,0.05285747],"study_design_scores_gemma":[0.7294631,0.2588911,0.006587617,0.00002449026,0.0003191679,0.0002435161,0.00003656145,0.001048786,0.001540965,0.0001368106,0.001685998,0.00002187976],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915152,0.001789239,0.0004031079,0.000482452,0.0001585085,0.001969663,0.001115918,0.0001197433,0.002446054],"genre_scores_gemma":[0.9850215,0.001760077,0.001570123,0.0009934076,0.0002364296,0.002116379,0.003870992,0.00003465578,0.004396443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004860018,"threshold_uncertainty_score":0.01625836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1768757287881299,"score_gpt":0.5258757551113273,"score_spread":0.3490000263231974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}