{"id":"W3081393016","doi":"10.1126/science.aax0701","title":"Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":384,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Agence Nationale de la Recherche","keywords":"Bacteriophage; Immune system; Antigen; Biology; Molecular mimicry; Epitope; Microbiology; Immunity; Immunology; Immunotherapy; T cell; Virology; Genetics; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124534,0.0002930622,0.0001123217,0.0003468485,0.0001756327,0.0005019438,0.0001202581,0.0007297623,0.002292225],"category_scores_gemma":[0.0002822173,0.0001569387,0.000188498,0.0002084299,0.0002365696,0.0002344121,0.0002302989,0.0007471609,0.0003372506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003161191,"about_ca_system_score_gemma":0.000123476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002449319,"about_ca_topic_score_gemma":0.0002777952,"domain_scores_codex":[0.9998872,0.00003090433,0.000007777624,0.00002094862,0.00003282262,0.00002033225],"domain_scores_gemma":[0.9998811,0.00003939186,0.00003027644,0.000005885567,0.00001900687,0.00002438411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002598359,0.000828464,0.02129571,0.0009394319,0.0002205857,0.006990469,0.0003332553,0.0004026072,0.8029218,0.006935699,0.01588969,0.1406438],"study_design_scores_gemma":[0.0001919353,0.003434452,0.2118629,0.0003712367,0.0002776863,0.02453541,0.0006510792,0.003221615,0.5355086,0.008719318,0.2111611,0.00006474897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8675431,0.09777535,0.002795021,0.004595423,0.002282537,0.00005267939,0.0001036426,0.00004866837,0.02480365],"genre_scores_gemma":[0.94598,0.03622043,0.0008554206,0.001466163,0.001332397,0.0000170217,0.0001919857,0.00001043077,0.0139262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002292225,"threshold_uncertainty_score":0.007668197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027329992397521,"score_gpt":0.2911429723994566,"score_spread":0.2708696724754814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}