{"id":"W3081394542","doi":"10.1093/function/zqaa013","title":"Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required","year":2020,"lang":"en","type":"article","venue":"Function","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa; McMaster University; University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Heart and Stroke Foundation of Canada","keywords":"Insulin resistance; Endocrinology; Adipose tissue; Internal medicine; Dysbiosis; Biology; Inflammation; Metabolic syndrome; Systemic inflammation; Gut flora; Fatty liver; Adipokine; Insulin; Obesity; Medicine; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002287639,0.0005961921,0.0002942976,0.0006361288,0.0002348235,0.0004103311,0.0001480381,0.0002566727,0.001309243],"category_scores_gemma":[0.0001304579,0.0002440848,0.0002691449,0.0004419753,0.0005051517,0.0002505773,0.0004866752,0.0007533507,0.0001751731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236391,"about_ca_system_score_gemma":0.0002600622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002950508,"about_ca_topic_score_gemma":0.0008835151,"domain_scores_codex":[0.9996972,0.00004919421,0.0000307008,0.000105401,0.00006877162,0.00004875862],"domain_scores_gemma":[0.999666,0.00001564914,0.0001716476,0.00004208563,0.00002460468,0.00008010194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008187346,0.0001077789,0.00818591,0.00008492562,0.00003978988,0.0001476061,0.00003507438,0.00004734881,0.9877428,0.0001594202,0.00004720273,0.002583442],"study_design_scores_gemma":[0.00009016327,0.003041277,0.5295738,0.00007600594,0.0002013148,0.002345671,0.000340127,0.0007553553,0.4591154,0.000597233,0.003824276,0.00003936411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942322,0.001925177,0.002133445,0.0001280604,0.00003178835,0.00002937672,0.0004412393,0.00006489675,0.001013814],"genre_scores_gemma":[0.9943728,0.001684894,0.001968913,0.0001070611,0.00002721607,0.00005710017,0.000456599,0.00001837108,0.001306911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309243,"threshold_uncertainty_score":0.004379869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019967649633648,"score_gpt":0.2540548270905471,"score_spread":0.2238551505942106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}