{"id":"W3081394542","doi":"10.1093/function/zqaa013","title":"Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required","year":2020,"lang":"en","type":"article","venue":"Function","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa; McMaster University; University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Heart and Stroke Foundation of Canada","keywords":"Insulin resistance; Endocrinology; Adipose tissue; Internal medicine; Dysbiosis; Biology; Inflammation; Metabolic syndrome; Systemic inflammation; Gut flora; Fatty liver; Adipokine; Insulin; Obesity; Medicine; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001414379,0.0002746321,0.0004737634,0.0001941088,0.0002023808,0.0000585295,0.00006603764,0.000289072,0.0002581026],"category_scores_gemma":[0.0004706958,0.0002734272,0.00007606691,0.0006173559,0.00002659157,0.0003587201,0.00005371723,0.0002704324,0.0005629263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008581468,"about_ca_system_score_gemma":0.00006978444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005342212,"about_ca_topic_score_gemma":0.0000728801,"domain_scores_codex":[0.9981208,0.0000887719,0.0004561773,0.0006230935,0.0004188279,0.0002922851],"domain_scores_gemma":[0.9987079,0.00004650122,0.0002095574,0.0003386189,0.0002724618,0.0004249495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004520861,0.00007390213,0.0006757898,0.0001886962,0.0001235441,0.00002026404,0.00196987,0.000002614777,0.932021,0.0001230863,0.02686267,0.03341769],"study_design_scores_gemma":[0.004715921,0.00136446,0.1472026,0.0002826221,0.0009106567,0.0000129408,0.0002790373,0.0001328309,0.2587948,0.00008740167,0.5857279,0.0004887419],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979827,0.0006087515,0.002066442,0.0122627,0.001765699,0.001336294,0.00003103284,0.0003408797,0.001761229],"genre_scores_gemma":[0.9860702,0.0001124004,0.001118261,0.0038501,0.004213598,0.00009049879,0.0001388133,0.00005351111,0.004352651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6732262,"threshold_uncertainty_score":0.9999718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019967649633648,"score_gpt":0.2540548270905471,"score_spread":0.2238551505942106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}