{"id":"W3081402497","doi":"10.1039/d0qo00827c","title":"Metal-free reductive coupling of aliphatic aldehydes/ketones with 4-cyanopyridines: expanded scope and mechanistic studies","year":2020,"lang":"en","type":"article","venue":"Organic Chemistry Frontiers","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Nanjing University; National Natural Science Foundation of China","keywords":"Chemistry; Pyridine; Coupling (piping); Scope (computer science); Metal; Combinatorial chemistry; Organic chemistry; Metallurgy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001859008,0.0003629137,0.0006848145,0.00002442097,0.0002006641,0.0000566108,0.000328104,0.0001306826,0.001320481],"category_scores_gemma":[0.001660651,0.0003397849,0.00007919472,0.0003951041,0.0003795309,0.0001406397,0.0002299063,0.0001834853,0.000002888809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001563066,"about_ca_system_score_gemma":0.0002124176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009142126,"about_ca_topic_score_gemma":0.00000132047,"domain_scores_codex":[0.9981694,0.00001002672,0.0004755967,0.0006382585,0.0004352698,0.0002714013],"domain_scores_gemma":[0.9984499,0.0001618005,0.0003557666,0.0005259247,0.0002962138,0.0002104105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002281492,0.00004832714,0.0003057307,0.001756274,0.0008631662,0.00001168019,0.0008477424,0.0001051606,0.9919301,0.00003996708,0.003736603,0.0001270488],"study_design_scores_gemma":[0.001518204,0.00003564442,0.000006299843,0.0001741688,0.0005966246,0.00005404835,0.01019666,0.001632761,0.984085,0.0005923163,0.0007267299,0.0003815208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9246508,0.01545505,0.05295319,0.002235876,0.0004153287,0.0004140748,0.0001766144,0.0004400491,0.003258971],"genre_scores_gemma":[0.9675201,0.001378515,0.02489655,0.0001844798,0.0005649646,0.0000716283,0.0002027371,0.0001958338,0.004985148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0428693,"threshold_uncertainty_score":0.9999054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02632479050837945,"score_gpt":0.2589624975967174,"score_spread":0.2326377070883379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}