{"id":"W3081416380","doi":"10.1016/j.ejmech.2020.112759","title":"Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec-Société et Culture; Crohn's and Colitis Canada; Higher Education Commission, Pakistan","keywords":"Chemistry; Oxazole; Cyclic nucleotide phosphodiesterase; Phosphodiesterase; Biochemistry; Enzyme; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693949,0.0005934131,0.0003890444,0.0004276539,0.0003457034,0.0002105584,0.0005718163,0.0004012036,0.004180918],"category_scores_gemma":[0.0001877247,0.0001967863,0.0003053562,0.000696595,0.0002318588,0.0002765513,0.0002865714,0.0006471727,0.0008218571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004309332,"about_ca_system_score_gemma":0.0004728743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001876488,"about_ca_topic_score_gemma":0.005226114,"domain_scores_codex":[0.9998672,0.00001441451,0.0000110721,0.00001464597,0.00002272982,0.00006992663],"domain_scores_gemma":[0.999941,0.000007587147,0.00001510151,0.000006784828,0.00001256565,0.00001696315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005198807,0.0003695026,0.0002839148,0.001005196,0.00006171884,0.001179423,0.0002582459,0.001939713,0.9526504,0.003655546,0.001948351,0.03612814],"study_design_scores_gemma":[0.0002770205,0.005319412,0.003622537,0.00008828996,0.000176639,0.0009694365,0.0001157671,0.002123568,0.9468375,0.0006169187,0.03977058,0.00008231131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9086869,0.02759091,0.02992064,0.0008475431,0.0003729433,0.0005073362,0.001958018,0.0005310113,0.02958462],"genre_scores_gemma":[0.9688461,0.01397169,0.007999542,0.0001983294,0.00005071432,0.0001764589,0.0009314427,0.00002618913,0.007799375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004180918,"threshold_uncertainty_score":0.01398653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782033416068383,"score_gpt":0.2527570126984703,"score_spread":0.2349366785377865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}