{"id":"W3081432089","doi":"10.3390/molecules25173854","title":"Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of 68Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Victoria General Hospital Foundation; BC Cancer Foundation","keywords":"DOTA; Biodistribution; Chemistry; Linker; Kidney; Ex vivo; In vivo; Brush border; PEGylation; Conjugated system; Molecular biology; Biochemistry; In vitro; Polyethylene glycol; Medicine; Chelation; Biology; Membrane; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299012,0.0003610921,0.0002919234,0.0001016106,0.00008155681,0.0002217616,0.0002144383,0.0003296957,0.0003499745],"category_scores_gemma":[0.000221658,0.0001334317,0.0002198016,0.0001128142,0.0001427669,0.0002358989,0.0001453719,0.000356826,0.0001102634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623934,"about_ca_system_score_gemma":0.0002423449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004269416,"about_ca_topic_score_gemma":0.0004877699,"domain_scores_codex":[0.9998655,0.00002665032,0.00001084691,0.00002952782,0.00004296264,0.00002449866],"domain_scores_gemma":[0.9998845,0.00001725477,0.00005023056,0.000005873754,0.00001650206,0.00002575042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109945,0.00003154307,0.00006449038,0.00004049874,0.000005796959,0.00002598777,0.000006008227,0.0001896356,0.9985429,0.00002778012,0.000008040816,0.0009463691],"study_design_scores_gemma":[0.00003996645,0.001347535,0.0006468447,0.000003310787,0.00002019302,0.0001645005,0.000007247848,0.001210552,0.9957383,0.000008288196,0.0008075076,0.000005850492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947864,0.00137517,0.003299014,0.00003929721,0.00001276948,0.00006189546,0.00007245269,0.00003001032,0.0003229307],"genre_scores_gemma":[0.9916078,0.0009421129,0.00632868,0.00004891924,0.000006516316,0.00004179738,0.0001592438,0.00001509107,0.0008499564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004269416,"threshold_uncertainty_score":0.001903832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05494096347161894,"score_gpt":0.3689887399111288,"score_spread":0.3140477764395099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}