{"id":"W3081432089","doi":"10.3390/molecules25173854","title":"Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of 68Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Victoria General Hospital Foundation; BC Cancer Foundation","keywords":"DOTA; Biodistribution; Chemistry; Linker; Kidney; Ex vivo; In vivo; Brush border; PEGylation; Conjugated system; Molecular biology; Biochemistry; In vitro; Polyethylene glycol; Medicine; Chelation; Biology; Membrane; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004661067,0.0001653743,0.0003697593,0.00004686965,0.00004630019,0.00001271663,0.0001052185,0.0000802113,0.0004126212],"category_scores_gemma":[0.001662132,0.0001539098,0.00007584402,0.0004018699,0.0001257473,0.00003753792,0.00005091117,0.0001707066,0.00002602491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002920997,"about_ca_system_score_gemma":0.0002880153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002032898,"about_ca_topic_score_gemma":5.938288e-7,"domain_scores_codex":[0.998377,0.00007189186,0.0004695058,0.0003307545,0.0005630231,0.0001878495],"domain_scores_gemma":[0.9985232,0.00006029119,0.0001305736,0.000260976,0.0005753495,0.0004496203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003090621,0.0001424705,0.0000518791,0.0001513112,0.0001678799,0.000004394809,0.0003331016,0.0001290914,0.9912587,0.0002094863,0.003046923,0.004195747],"study_design_scores_gemma":[0.002551599,0.0002921517,0.0006287304,0.000128457,0.0009283795,0.00001782004,0.0001291039,0.007338106,0.9802377,0.0001663181,0.007444907,0.0001367373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879391,0.0005513256,0.0003235844,0.005809514,0.00001501155,0.0006248077,0.00004486528,0.00003839855,0.004653447],"genre_scores_gemma":[0.9906425,0.00005330225,0.007234538,0.001524963,0.0000813402,0.00005552906,0.00005172082,0.00002524187,0.0003308357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102096,"threshold_uncertainty_score":0.6276261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05494096347161894,"score_gpt":0.3689887399111288,"score_spread":0.3140477764395099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}