{"id":"W3081466185","doi":"10.1042/bcj20200260","title":"Sunitinib inhibits RNase L by destabilizing its active dimer conformation","year":2020,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Sunitinib; Ribonuclease; RNase P; RNase H; Dimer; Binding site; Chemistry; RNase PH; Biochemistry; Biology; RNA; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444465,0.000216879,0.0003252823,0.00008460676,0.0001623895,0.000257335,0.0002758661,0.0002714725,0.00100733],"category_scores_gemma":[0.0001280828,0.000111469,0.0003461092,0.00005162154,0.0001830268,0.0002257129,0.0001411083,0.000424724,0.0002759358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002785523,"about_ca_system_score_gemma":0.0002841189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004043127,"about_ca_topic_score_gemma":0.0005995427,"domain_scores_codex":[0.9998717,0.00002491292,0.000009473072,0.00002891281,0.0000341022,0.00003093867],"domain_scores_gemma":[0.9999521,0.000008900132,0.00001610364,0.000003356094,0.000006393149,0.00001318947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059428,0.00005816006,0.0005391926,0.000123534,0.00004087851,0.0001039054,0.00002306169,0.0009766184,0.9929015,0.0003123952,0.0002549185,0.004459893],"study_design_scores_gemma":[0.00008140304,0.0004006042,0.001604231,0.000006028636,0.00002630582,0.0003375139,0.00002523717,0.008215285,0.9848814,0.0001448835,0.00426245,0.00001472527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861615,0.004242729,0.006970609,0.0002021105,0.00006518402,0.0000271631,0.0000982369,0.0001956156,0.002036943],"genre_scores_gemma":[0.9968291,0.0005273018,0.001560659,0.00008712973,0.000007000827,0.000009730082,0.0001192825,0.00001230447,0.0008475058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00100733,"threshold_uncertainty_score":0.003369808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03101539825953472,"score_gpt":0.2993745917624876,"score_spread":0.2683591935029529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}