{"id":"W3081495557","doi":"10.1093/brain/awaa222","title":"Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; National Institutes of Health; H. Lundbeck A/S; Servier; Deutsche Forschungsgemeinschaft; Fujirebio US; Northern California Institute for Research and Education; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Takeda Pharmaceutical Company; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; National Institute on Aging; Alzheimer's Association; Helmholtz-Gemeinschaft","keywords":"Hippocampus; Dementia; Neuroscience; Psychology; Atrophy; Cognition; Voxel-based morphometry; Disease; Medicine; Pathology; White matter; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100209,0.0001761578,0.0003502223,0.0008466867,0.0001974797,0.0003408522,0.0001980627,0.0002516031,0.0007902545],"category_scores_gemma":[0.002936708,0.0001925542,0.00032542,0.0004407279,0.0004271262,0.0002874449,0.0004448792,0.0002119702,0.0001379282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001471502,"about_ca_system_score_gemma":0.0001998166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002454638,"about_ca_topic_score_gemma":0.006118445,"domain_scores_codex":[0.9995437,0.0001108913,0.00005008651,0.00020268,0.00005807854,0.00003454376],"domain_scores_gemma":[0.9988323,0.0002726407,0.0003640358,0.0003257538,0.0001373047,0.00006808754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007284177,0.00004256457,0.9288452,0.00007809979,0.0007469332,0.000308799,0.001066818,0.0009022972,0.04833487,0.0005328009,0.0003677549,0.01804547],"study_design_scores_gemma":[0.000002736207,0.00004571087,0.9977291,0.000004665844,0.00003089119,0.0002569059,0.00007726516,0.0006466961,0.0007189735,0.0003913868,0.00009148868,0.000004157334],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971551,0.0002167638,0.002067749,0.00002715219,0.000003425183,0.000005065993,0.0002842896,0.00002308644,0.0002173024],"genre_scores_gemma":[0.9991647,0.00003062297,0.0004983633,0.0000100581,0.000001939086,0.000004143693,0.0001954682,0.000006476651,0.00008830976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002454638,"threshold_uncertainty_score":0.005299628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336980519172294,"score_gpt":0.3269834946135808,"score_spread":0.2936136894218579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}