{"id":"W3081572286","doi":"10.1158/1557-3265.ovca19-b25","title":"Abstract B25: SMARCA4/BRG1 and AP-1 co-regulate an epithelial-like signature in small-cell carcinoma of ovary, hypercalcemic type (SCCOHT)","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"SMARCA4; Biology; Carcinogenesis; Transcription factor; Chromatin immunoprecipitation; Gene; Cancer research; Chromatin remodeling; Molecular biology; Gene expression; Cell biology; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001175118,0.0001752101,0.0003506482,0.00005656004,0.00006182987,0.00002503965,0.0003938699,0.0004246807,0.0001230388],"category_scores_gemma":[0.0002437421,0.000158646,0.0001042916,0.0002467814,0.000361913,0.000006682507,0.0002086506,0.0007929648,0.00001201247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003218689,"about_ca_system_score_gemma":0.0005610968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007479701,"about_ca_topic_score_gemma":0.0003545283,"domain_scores_codex":[0.9977646,0.0002777034,0.0005523961,0.0006983621,0.0002831137,0.0004238621],"domain_scores_gemma":[0.9987552,0.0001284494,0.00009454595,0.0004311425,0.0002707852,0.000319842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002187395,0.0002647335,0.04264642,0.000318584,0.00004364757,0.00002619244,0.0002164012,0.0003045714,0.9335815,0.000007913924,0.003629338,0.01677331],"study_design_scores_gemma":[0.01046635,0.006778073,0.3558257,0.0003084305,0.0000821697,0.00001421297,0.0006545213,0.006144435,0.5859774,0.0004859686,0.03193532,0.001327397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927673,0.005658423,0.00001156635,0.000525267,0.0001306563,0.0002841944,0.0000750743,0.000009823441,0.0005376874],"genre_scores_gemma":[0.9959397,0.002520362,0.0001628883,0.0005007064,0.0005539203,0.00002048501,0.00007505732,0.00004005156,0.0001868608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.347604,"threshold_uncertainty_score":0.6469395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1448932915789845,"score_gpt":0.4363896479653528,"score_spread":0.2914963563863683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}