{"id":"W3081578962","doi":"10.1007/s00702-020-02247-2","title":"The MPTP-lesioned marmoset model of Parkinson’s disease: proposed efficacy thresholds that may potentially predict successful clinical trial results","year":2020,"lang":"en","type":"review","venue":"Journal of Neural Transmission","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; McGill University Health Centre; Université de Montréal","funders":"","keywords":"Marmoset; MPTP; Parkinson's disease; Neuroscience; Neurology; Medicine; Disease; Clinical trial; Psychology; Physical medicine and rehabilitation; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001391572,0.0008031399,0.003457408,0.000228117,0.0002640865,0.00009005521,0.0008195795,0.0005058067,0.00003483133],"category_scores_gemma":[0.0004122034,0.000399025,0.003860655,0.000329496,0.0001821554,0.0001869612,0.0000923502,0.001417445,0.000006277899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269371,"about_ca_system_score_gemma":0.002274928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001986903,"about_ca_topic_score_gemma":3.959626e-7,"domain_scores_codex":[0.9921881,0.0009864459,0.003630287,0.0007203252,0.001972655,0.0005022117],"domain_scores_gemma":[0.9937292,0.0006735798,0.003020916,0.0007122641,0.0002898604,0.00157419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1599139,0.001809257,0.00005931583,0.003652608,0.001042917,0.001715331,0.00002448536,0.00002767332,0.00001345802,0.000005394014,0.001479959,0.8302557],"study_design_scores_gemma":[0.06662073,0.004793716,0.0006139817,0.01737403,0.01153228,0.0002224261,0.000009243656,0.001721975,0.00002141749,0.00008852754,0.8966249,0.0003768375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004481098,0.9870135,0.0005768294,0.002365444,0.001251324,0.003647026,0.0005303635,0.00004923219,0.00008520235],"genre_scores_gemma":[0.04119923,0.9565324,0.0007540161,0.00007234982,0.0008696615,0.00001982991,0.0001665405,0.0001146159,0.0002713737],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8951449,"threshold_uncertainty_score":0.9998462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1514580757335959,"score_gpt":0.3985446254953848,"score_spread":0.2470865497617889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}