{"id":"W3081614355","doi":"10.1016/j.tibtech.2020.07.012","title":"Gene Delivery to the Skin – How Far Have We Come?","year":2020,"lang":"en","type":"review","venue":"Trends in biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"NanoMedicines Innovation Network; BC Innovation Council; University of British Columbia","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Gene; Gene delivery; Computational biology; Biology; Genetics; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001088476,0.001161801,0.001910873,0.001066608,0.0002379162,0.001519411,0.001293855,0.001932444,0.003473342],"category_scores_gemma":[0.0008156757,0.0003451495,0.0004907182,0.001301203,0.000991941,0.002277479,0.0007084666,0.003291069,0.002933586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000891404,"about_ca_system_score_gemma":0.001126027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155628,"about_ca_topic_score_gemma":0.00230888,"domain_scores_codex":[0.9997409,0.00004619913,0.00002400563,0.00004521522,0.0001063272,0.00003742212],"domain_scores_gemma":[0.9997035,0.0001455094,0.00003540183,0.00001177884,0.00006541243,0.00003837167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000174098,0.00007597476,0.00009464621,0.0136722,0.00006745778,0.0002226649,0.00005563592,0.0003908506,0.007045241,0.009771643,0.05133352,0.9170961],"study_design_scores_gemma":[0.00003340795,0.00009851436,0.0003112456,0.002194849,0.00007590192,0.0007976537,0.00005298773,0.0001036852,0.001438407,0.003397987,0.9914747,0.00002071144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004998887,0.9981805,0.0002362403,0.0004569068,0.0003978771,0.000002667766,0.000007565531,0.000008541631,0.000659671],"genre_scores_gemma":[0.0003808124,0.9982119,0.0002175814,0.0003484229,0.0001835801,0.000005029709,0.0000138332,0.000002500183,0.0006364671],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003473342,"threshold_uncertainty_score":0.01161951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574682566953685,"score_gpt":0.3047246200198424,"score_spread":0.2689777943503055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}