{"id":"W3081614355","doi":"10.1016/j.tibtech.2020.07.012","title":"Gene Delivery to the Skin – How Far Have We Come?","year":2020,"lang":"en","type":"review","venue":"Trends in biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"NanoMedicines Innovation Network; BC Innovation Council; University of British Columbia","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Gene; Gene delivery; Computational biology; Biology; Genetics; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000137235,0.0005534909,0.001077382,0.0005456638,0.00006715138,0.00003996257,0.001515768,0.001653567,0.00004285878],"category_scores_gemma":[0.00005801601,0.0003993787,0.0004540682,0.0006925156,0.0001802144,0.000002640881,0.0008810072,0.0007309375,0.0001939586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000622037,"about_ca_system_score_gemma":0.0001024808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003078748,"about_ca_topic_score_gemma":0.0005740579,"domain_scores_codex":[0.9978253,0.0001476942,0.0004377646,0.0009456594,0.0001301762,0.0005134079],"domain_scores_gemma":[0.9985258,0.00002135528,0.0001975081,0.001132366,0.0000355815,0.0000873952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001502257,0.00002796058,0.000002163376,0.0001613479,0.0001440128,0.00004792066,0.00002268668,0.000002140208,0.0008330772,0.00003197886,0.01736339,0.9813483],"study_design_scores_gemma":[0.0001436801,0.0004044639,0.00000377744,0.000331545,0.0001126129,0.0001097703,0.00004928833,0.00000434572,0.006215142,0.000009798957,0.992186,0.0004296086],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000346688,0.990313,0.0001354185,0.008104078,0.0003205628,0.0003090065,0.0001752269,0.00004875691,0.0002472541],"genre_scores_gemma":[0.001111883,0.9952181,0.0003289361,0.0005412315,0.0003431174,0.0001577124,0.0004244014,0.00006446138,0.001810186],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809187,"threshold_uncertainty_score":0.9998458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574682566953685,"score_gpt":0.3047246200198424,"score_spread":0.2689777943503055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}