{"id":"W3081708016","doi":"10.1101/2020.08.28.273029","title":"Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Institutes of Health; University of Toronto","keywords":"Biology; Transcriptome; Cancer research; Breast cancer; Population; Cancer; Genetics; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007232107,0.00009532851,0.0001180819,0.0003805018,0.0001878608,0.0003690773,0.0001065688,0.0002828592,0.00193628],"category_scores_gemma":[0.0001338171,0.00008835792,0.0001149676,0.0001465078,0.0001064176,0.0002351289,0.0003914392,0.0003326043,0.0004394923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001989343,"about_ca_system_score_gemma":0.0001255078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003453166,"about_ca_topic_score_gemma":0.0003263851,"domain_scores_codex":[0.9999477,0.000005115379,0.000003303512,0.00001403558,0.00001381712,0.00001598144],"domain_scores_gemma":[0.9998699,0.00001681581,0.00004163604,0.00001065926,0.00001897248,0.00004206236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000251336,0.00003693101,0.0187907,0.00003347485,0.0000077971,0.0002719501,0.0001387989,0.0001153989,0.9715971,0.0005011716,0.0001495223,0.00810585],"study_design_scores_gemma":[0.00002483212,0.001274901,0.711408,0.00003651691,0.00004246576,0.00470702,0.00100929,0.002918931,0.2622378,0.001287441,0.01502117,0.00003167456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968533,0.0008341142,0.0006257482,0.0000458279,0.000005981512,0.00001437875,0.0004046856,0.00002192211,0.001194175],"genre_scores_gemma":[0.9964203,0.0003990788,0.0003371546,0.00003694071,0.000005787517,0.0000256787,0.0004063217,0.000009759606,0.002358977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00193628,"threshold_uncertainty_score":0.006477535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03001084972692341,"score_gpt":0.2853499626939349,"score_spread":0.2553391129670115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}