{"id":"W3081763406","doi":"10.3390/membranes10090215","title":"Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization","year":2020,"lang":"en","type":"article","venue":"Membranes","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Foundation; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Transmembrane domain; Virology; Glycoprotein; Transmembrane protein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus; Domain (mathematical analysis); Spike Protein; Spike (software development); Computational biology; Receptor; Lipid bilayer fusion; Pandemic; Epitope; Coronavirus disease 2019 (COVID-19); Biology; Medicine; Immunology; Antibody; Virus; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006327304,0.0003041928,0.0006643879,0.0003551027,0.0001961332,0.00004004718,0.000335636,0.0002084084,0.00003032912],"category_scores_gemma":[0.0003667731,0.0002719973,0.0002062631,0.001344339,0.00005409755,0.0001618968,0.00005554416,0.0002073825,0.0000705763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008119547,"about_ca_system_score_gemma":0.0002735846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007694736,"about_ca_topic_score_gemma":0.00001504126,"domain_scores_codex":[0.9976782,0.0001388399,0.0006676326,0.0006149989,0.0004216714,0.0004786395],"domain_scores_gemma":[0.9987782,0.0002711421,0.0001604656,0.0004213869,0.0002586193,0.0001102007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00298733,0.000172479,0.0003871492,0.0008405441,0.00007072817,0.000004335662,0.001590148,0.000006474058,0.9852141,0.000210234,0.000696166,0.007820293],"study_design_scores_gemma":[0.003879659,0.001132057,0.0003647178,0.0001606363,0.00006808561,0.00001218071,0.0002723201,0.00008457334,0.9403396,0.0003653535,0.05306736,0.0002534336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9269152,0.0002865784,0.05341392,0.01518573,0.00009136074,0.003550775,0.00007745651,0.0001439568,0.000334977],"genre_scores_gemma":[0.9631003,0.00002462128,0.01938514,0.0161651,0.000429553,0.0006760995,0.00009425935,0.000103565,0.0000213222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05237119,"threshold_uncertainty_score":0.9999732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08358732616493501,"score_gpt":0.355137322826698,"score_spread":0.2715499966617629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}