{"id":"W3081763406","doi":"10.3390/membranes10090215","title":"Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization","year":2020,"lang":"en","type":"article","venue":"Membranes","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Foundation; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Transmembrane domain; Virology; Glycoprotein; Transmembrane protein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus; Domain (mathematical analysis); Spike Protein; Spike (software development); Computational biology; Receptor; Lipid bilayer fusion; Pandemic; Epitope; Coronavirus disease 2019 (COVID-19); Biology; Medicine; Immunology; Antibody; Virus; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006078749,0.0004493215,0.00034035,0.00009700212,0.0002857113,0.0004475475,0.000325087,0.0007345299,0.003746721],"category_scores_gemma":[0.0005747385,0.0001131136,0.0002201653,0.0001136259,0.0003497812,0.000855846,0.0002148798,0.0007207961,0.0007149915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006383631,"about_ca_system_score_gemma":0.0005129845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004277436,"about_ca_topic_score_gemma":0.0004991229,"domain_scores_codex":[0.9998657,0.00005658859,0.000008819604,0.00001882072,0.00002199779,0.00002805309],"domain_scores_gemma":[0.9998909,0.00004296144,0.00001980506,0.000008031601,0.00001944631,0.00001890335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005595759,0.0001969404,0.00117736,0.0002315581,0.00001449603,0.0004896207,0.00009036352,0.002087972,0.9742416,0.006890572,0.001545379,0.01247453],"study_design_scores_gemma":[0.0002032635,0.002112855,0.006149956,0.0001134008,0.00004659264,0.001499441,0.0006191471,0.01149642,0.9184289,0.01258509,0.04671985,0.00002502995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8501974,0.0297315,0.06187754,0.03855213,0.001056613,0.0003245128,0.0008256356,0.0002880439,0.01714659],"genre_scores_gemma":[0.9663802,0.008695089,0.01799929,0.001792703,0.0001578286,0.000103032,0.0005221819,0.00002132284,0.00432837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003746721,"threshold_uncertainty_score":0.01253402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08358732616493501,"score_gpt":0.355137322826698,"score_spread":0.2715499966617629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}