{"id":"W3081783793","doi":"10.1093/narcan/zcaa019","title":"The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; Montreal Clinical Research Institute","funders":"National Institute of General Medical Sciences; Helse Sør-Øst RHF; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; National Health Insurance Administration; Leukemia and Lymphoma Society of Canada; Kreftforeningen; Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society","keywords":"Uracil-DNA glycosylase; Biology; B cell; Cancer research; Cancer cell; Suppressor; DNA glycosylase; DNA repair; Molecular biology; Cancer; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008500949,0.0002113039,0.0001170083,0.0001750767,0.00008203658,0.0001885193,0.0001240027,0.000169651,0.0007329349],"category_scores_gemma":[0.00007874456,0.0000728772,0.00008150798,0.00007225806,0.0001627878,0.00009413763,0.0001891856,0.0002418271,0.0001741542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001171339,"about_ca_system_score_gemma":0.0000901854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001715868,"about_ca_topic_score_gemma":0.0002020514,"domain_scores_codex":[0.9999264,0.00001741683,0.000004951577,0.00001328472,0.00001530948,0.00002261057],"domain_scores_gemma":[0.9999219,0.00001357158,0.00002153444,0.00001268589,0.000004967641,0.00002518971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011101,0.0000142852,0.0002045641,0.0000119297,0.000002353459,0.00001276116,0.000004378516,0.00003293186,0.9985398,0.0000838358,0.000009906229,0.0009721679],"study_design_scores_gemma":[0.000008996382,0.0003988327,0.002953861,0.000003783717,0.000007362758,0.0001662596,0.00001123555,0.0003381832,0.9947407,0.00005315198,0.001316344,0.000001425052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997322,0.00101483,0.0009095383,0.00002593663,0.000009234804,0.000006626912,0.00006802934,0.00003483564,0.0006089847],"genre_scores_gemma":[0.9985576,0.0002386224,0.0004300742,0.00001591687,0.000003665475,0.000005042904,0.00009002985,0.000006495156,0.0006525144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007329349,"threshold_uncertainty_score":0.002451897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584434596251727,"score_gpt":0.250045136022693,"score_spread":0.2342007900601757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}