{"id":"W3081783793","doi":"10.1093/narcan/zcaa019","title":"The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; Montreal Clinical Research Institute","funders":"National Institute of General Medical Sciences; Helse Sør-Øst RHF; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; National Health Insurance Administration; Leukemia and Lymphoma Society of Canada; Kreftforeningen; Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society","keywords":"Uracil-DNA glycosylase; Biology; B cell; Cancer research; Cancer cell; Suppressor; DNA glycosylase; DNA repair; Molecular biology; Cancer; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196171,0.0001558363,0.0002038516,0.00001810297,0.0005506806,0.0000298025,0.0002855381,0.0001265408,0.0003659535],"category_scores_gemma":[0.00005681974,0.00008652159,0.00006995045,0.000131915,0.0004495027,0.00009720195,0.00008992106,0.0003139751,0.00001722516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002643065,"about_ca_system_score_gemma":0.0001720822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004610518,"about_ca_topic_score_gemma":0.00004604717,"domain_scores_codex":[0.9989551,0.0002768189,0.000234924,0.0001882812,0.00004989863,0.0002949692],"domain_scores_gemma":[0.9992666,0.0002639069,0.0001642461,0.0002198943,0.00006931075,0.00001610569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0018665,0.00001531884,0.0001424095,0.0000398737,0.000158233,0.000001528083,0.003125028,0.0000537628,0.9316038,0.00002981255,0.002089994,0.06087371],"study_design_scores_gemma":[0.0008735333,0.00008900591,0.0005557108,0.00006860578,0.00002467444,0.000005756347,0.0004235808,0.00002158822,0.7403952,0.000005867281,0.2574368,0.00009973472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8757725,0.1199525,0.00003859908,0.003155346,0.0004138048,0.0004267884,0.00005099746,0.00002871665,0.0001607806],"genre_scores_gemma":[0.9919289,0.005481088,0.000007741366,0.0007210702,0.00007321484,0.0001553167,0.000002867527,0.00001871707,0.001611058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2553467,"threshold_uncertainty_score":0.4235446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584434596251727,"score_gpt":0.250045136022693,"score_spread":0.2342007900601757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}