{"id":"W3081793749","doi":"10.1126/sciadv.abb4591","title":"The NEMP family supports metazoan fertility and nuclear envelope stiffness","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Hospital for Sick Children; Genome Canada; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of General Medical Sciences; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Heart, Lung, and Blood Institute; Krembil Foundation; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Canada Research Chairs; Wellcome Trust","keywords":"Softening; Envelope (radar); Fertility; Stiffness; Computer science; Biology; Medicine; Materials science; Structural engineering; Engineering; Telecommunications; Composite material; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156482,0.00007079248,0.00005822109,0.000008394469,0.0004092299,0.00007520324,0.0002086719,0.00002438986,0.000008099157],"category_scores_gemma":[0.0001141279,0.00004574445,0.000019554,0.0001477705,0.0005614233,0.00002279429,0.000117444,0.00004864689,0.000006554498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003490201,"about_ca_system_score_gemma":0.00004725234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004624778,"about_ca_topic_score_gemma":0.00000811629,"domain_scores_codex":[0.9992877,0.00001461746,0.0000823751,0.0003044436,0.0001421033,0.0001687397],"domain_scores_gemma":[0.999661,0.000006168847,0.00003501704,0.0001580042,0.00004680985,0.00009302999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009465295,0.000003762804,0.001187843,0.000005804249,0.000004677189,9.89077e-7,0.0001324264,0.000006771643,0.8777159,0.0001824562,0.0002868013,0.1203779],"study_design_scores_gemma":[0.0001874521,0.0002144392,0.2508506,0.000002746084,0.00001029345,0.000005118287,0.001072444,0.00007170944,0.04159196,0.0005286343,0.7052842,0.0001803898],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959729,0.001205084,0.000075238,0.0008159247,0.0002251912,0.00006707855,0.000002545151,0.00001240001,0.001623583],"genre_scores_gemma":[0.9984339,0.0001265197,0.000336938,0.0009712788,0.00006029014,0.000001511098,0.000002009518,0.00000528542,0.00006223161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.836124,"threshold_uncertainty_score":0.3147507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008547457033985023,"score_gpt":0.2403566186406681,"score_spread":0.2318091616066831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}