{"id":"W3081861280","doi":"10.1158/1538-7445.am2020-ct169","title":"Abstract CT169: A phase Ia study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in patients with locally advanced or metastatic solid tumors","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chills; Immunotherapy; Internal medicine; Adverse effect; Cancer; Immune system; Oncology; Nausea; Gastroenterology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00071073,0.001111097,0.001258398,0.0003119293,0.000322411,0.0007041607,0.0006521586,0.0007591575,0.00318934],"category_scores_gemma":[0.0003996584,0.0002664908,0.000724379,0.0003426308,0.0005679232,0.0004969446,0.0002860441,0.00241997,0.001030963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006999269,"about_ca_system_score_gemma":0.001668597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007227131,"about_ca_topic_score_gemma":0.001399019,"domain_scores_codex":[0.9997695,0.00009094369,0.00001416091,0.00004211151,0.00003018637,0.00005315039],"domain_scores_gemma":[0.9996428,0.0000342031,0.00005572314,0.00002535416,0.00002258259,0.0002192035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.374165,0.1122366,0.01416513,0.001938747,0.001103047,0.0012874,0.0004245644,0.005772534,0.2969858,0.001068433,0.008476689,0.1823761],"study_design_scores_gemma":[0.1461124,0.8248275,0.008995096,0.0000577807,0.0002559951,0.0008415605,0.00006472033,0.001230762,0.01322398,0.0001541334,0.004207153,0.00002884953],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920013,0.001570867,0.0007011967,0.000292642,0.0001132284,0.002046886,0.001065193,0.0001042052,0.002104595],"genre_scores_gemma":[0.9891459,0.001198982,0.001572551,0.00045208,0.0001173407,0.001795903,0.003093354,0.00002520755,0.002598736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00318934,"threshold_uncertainty_score":0.01066947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1194957155376572,"score_gpt":0.4719475528965949,"score_spread":0.3524518373589377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}