{"id":"W3081954160","doi":"10.1080/13543776.2020.1817390","title":"Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract – A review of patent literature","year":2020,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Patents","topic":"Liver physiology and pathology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Proteases; TMPRSS2; Respiratory tract; Transmembrane protein; Serine; Biology; Medicine; Pharmacology; Respiratory system; Immunology; Enzyme; Receptor; Coronavirus disease 2019 (COVID-19); Biochemistry; Pathology; Disease; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618484,0.0003709147,0.002145432,0.0001103079,0.00002835606,0.000001070474,0.0002934875,0.0002288625,0.00004200119],"category_scores_gemma":[0.00004187227,0.0001643988,0.0008148279,0.0005579913,0.0001973526,0.00002347669,0.00002384516,0.000234994,0.000001280675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004082172,"about_ca_system_score_gemma":0.0002758442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001126739,"about_ca_topic_score_gemma":1.303541e-7,"domain_scores_codex":[0.9971341,0.00105863,0.001031989,0.0003036013,0.0003203541,0.0001513048],"domain_scores_gemma":[0.9982332,0.0001726389,0.0007781995,0.0006555789,0.000112839,0.00004753468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001106764,0.008025639,0.0006626801,0.1212062,0.000921697,0.00003361584,0.004097023,6.699681e-7,0.0009161627,0.00006412814,0.0001509624,0.8628144],"study_design_scores_gemma":[0.002267442,0.01018801,0.00416334,0.2507744,0.0007229642,0.00003902037,0.00006705682,9.362129e-7,0.001255349,0.00003036921,0.7302465,0.0002445825],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001345741,0.9949325,1.881386e-7,0.0002466268,0.0003467814,0.002871931,0.0002311787,0.000006456779,0.0000185947],"genre_scores_gemma":[0.0123601,0.9865409,0.000004322924,0.000569951,0.0001096472,0.0002130852,0.0001656229,0.0000263915,0.00001001279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8625699,"threshold_uncertainty_score":0.6703987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1508476443493234,"score_gpt":0.3814635435339384,"score_spread":0.230615899184615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}