{"id":"W3081986341","doi":"10.3389/fimmu.2020.02102","title":"In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Peptidomimetic; Inflammation; In vivo; Medicine; Anti-inflammatory; Pharmacology; Chemistry; Immunology; Biology; Biochemistry; Peptide; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888995,0.0005294805,0.0003516469,0.0001967193,0.0000795181,0.0001315219,0.0001800841,0.0002862121,0.001059305],"category_scores_gemma":[0.000129523,0.0001617622,0.0002183694,0.0001216218,0.0001470831,0.0002196683,0.00008584718,0.0007218341,0.0001935469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001076986,"about_ca_system_score_gemma":0.0001594226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001967867,"about_ca_topic_score_gemma":0.0002476826,"domain_scores_codex":[0.9998884,0.00002544542,0.0000116896,0.00001716369,0.00002199223,0.00003517166],"domain_scores_gemma":[0.9998822,0.00002407768,0.00003640384,0.000008336336,0.000009058488,0.00003997707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001880476,0.0004926787,0.00008420971,0.00006980678,0.00001040576,0.00004091841,0.00001315404,0.0001852746,0.9957339,0.0000264843,0.00003696812,0.001425673],"study_design_scores_gemma":[0.0003040073,0.01725249,0.003567038,0.00000805644,0.00005005801,0.0002046938,0.00001893852,0.001100453,0.9765338,0.00002370764,0.0009287338,0.000008085529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973593,0.001124519,0.0006303486,0.0000412471,0.00003658618,0.00003750906,0.0002549342,0.00002592958,0.0004895158],"genre_scores_gemma":[0.9953967,0.001304443,0.00101598,0.00004826099,0.00002580979,0.0000797451,0.0005277074,0.00000753323,0.001593801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059305,"threshold_uncertainty_score":0.003543675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008449449772736073,"score_gpt":0.209728792195223,"score_spread":0.201279342422487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}