{"id":"W3081986849","doi":"10.1158/0008-5472.can-20-1387","title":"Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; National Institute for Health and Care Research; Ontario Ministry of Economic Development and Innovation; UCLH Biomedical Research Centre; Cancer Research UK; Sarcoma UK; Bone Cancer Research Trust; European Federation of Pharmaceutical Industries and Associations; Fondation Leducq; Merck KGaA; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Pfizer; University College London Hospitals NHS Foundation Trust; Rosetrees Trust; European Commission; Chordoma Foundation; NIHR Oxford Biomedical Research Centre; Wellcome Trust; Medical Research Council; Ministero dello Sviluppo Economico; National Institute on Handicapped Research","keywords":"Brachyury; H3K4me3; Biology; Cancer research; Demethylating agent; Histone; Epigenetics; Chordoma; Cell biology; Genetics; Embryonic stem cell; Gene expression; DNA methylation; DNA; Mesoderm; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004516539,0.0001601252,0.0002079463,0.0001313847,0.000132031,0.00003247254,0.0002084891,0.0002001096,0.0001208864],"category_scores_gemma":[0.0003947353,0.0001617113,0.00006537353,0.0003966138,0.0002713616,0.00001074605,0.0004010688,0.0004270441,0.000006515289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009377162,"about_ca_system_score_gemma":0.0004174069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000358583,"about_ca_topic_score_gemma":0.00004379792,"domain_scores_codex":[0.9979602,0.0002556799,0.000225022,0.000573192,0.0005276107,0.00045834],"domain_scores_gemma":[0.9989665,0.00005065925,0.0000666097,0.0002924338,0.0003670803,0.0002567177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003869459,0.00006787704,0.0001185679,0.0002394446,0.00004038027,0.00001246501,0.0001465893,0.00002829512,0.9937087,0.0000816595,0.001460862,0.003708244],"study_design_scores_gemma":[0.0007492619,0.0009829877,0.0001459094,0.00005028327,0.00001088896,0.000004356575,0.0001379237,0.00009824263,0.9911135,0.0001595658,0.00638984,0.0001571693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883481,0.007828307,0.001390611,0.0009414873,0.00003699393,0.000557187,0.0000584679,0.0000154284,0.0008234142],"genre_scores_gemma":[0.9963273,0.002465374,0.0003152317,0.00013102,0.0002187827,0.0001505356,0.00005812492,0.00004796757,0.0002856166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007979244,"threshold_uncertainty_score":0.6594394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04615449414384994,"score_gpt":0.3797173927107848,"score_spread":0.3335628985669348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}