{"id":"W3082024221","doi":"10.1016/j.cell.2020.09.007","title":"High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Avidity; Biology; Bivalent (engine); Antibody; Mutant; Virology; Neutralization; Glycoprotein; Mutagenesis; Coronavirus; Potency; Molecular biology; In vitro; Phage display; Virus; Biochemistry; Coronavirus disease 2019 (COVID-19); Chemistry; Immunology; Gene; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001925898,0.0001498532,0.000366571,0.0001509685,0.00003043845,0.00001052743,0.0002100627,0.0001059755,0.00002051615],"category_scores_gemma":[0.00003037514,0.0001352224,0.0001105906,0.0003814057,0.00008542609,0.0000684497,0.0001166114,0.0002987137,0.00009065841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007240153,"about_ca_system_score_gemma":0.000155132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005926313,"about_ca_topic_score_gemma":0.00002878689,"domain_scores_codex":[0.9985088,0.00005539801,0.0003414977,0.0003357464,0.0004182902,0.0003403046],"domain_scores_gemma":[0.999498,0.00003342715,0.00005979115,0.0002917664,0.00007121484,0.00004585537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003379551,0.0002874842,0.002572794,0.0003365791,0.00001352938,0.0002326461,0.001052928,0.000003109576,0.9933114,0.0007227187,0.0009284455,0.0002004347],"study_design_scores_gemma":[0.002807636,0.0008546138,0.001405059,0.00006864307,0.00002048151,0.000004888628,0.0001964146,0.001218726,0.9848078,0.002158668,0.006313421,0.0001436463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847819,0.0003672485,0.0001944946,0.000929629,0.00003107111,0.0003618143,0.000008361778,0.00004127977,0.01328417],"genre_scores_gemma":[0.9860716,0.000005527646,0.0004434607,0.01327136,0.0001262456,0.00001617225,0.000003717225,0.00002876483,0.0000330945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01325108,"threshold_uncertainty_score":0.5514209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07500050226641847,"score_gpt":0.3395248832572056,"score_spread":0.2645243809907871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}