{"id":"W3082024221","doi":"10.1016/j.cell.2020.09.007","title":"High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Avidity; Biology; Bivalent (engine); Antibody; Mutant; Virology; Neutralization; Glycoprotein; Mutagenesis; Coronavirus; Potency; Molecular biology; In vitro; Phage display; Virus; Biochemistry; Coronavirus disease 2019 (COVID-19); Chemistry; Immunology; Gene; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003801198,0.0003940537,0.0003197235,0.0003461899,0.0001902348,0.0004992304,0.0003382634,0.0004873424,0.001929601],"category_scores_gemma":[0.0002172847,0.0001180499,0.0002364754,0.0001864352,0.0002789896,0.0003276842,0.0001960448,0.001085389,0.0004550146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004338173,"about_ca_system_score_gemma":0.0002772712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001234401,"about_ca_topic_score_gemma":0.001256117,"domain_scores_codex":[0.9997012,0.00007319732,0.00001869372,0.00004700596,0.0000676507,0.00009222088],"domain_scores_gemma":[0.9998416,0.00005051004,0.00001936644,0.00003062441,0.00002069596,0.00003724768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005787688,0.0003590855,0.0002061302,0.0000500459,0.00001503558,0.00005766893,0.00003686551,0.0003903273,0.9950548,0.0003927524,0.0002844838,0.002573922],"study_design_scores_gemma":[0.00009463532,0.003689541,0.001558975,0.00001313241,0.00004080245,0.000264567,0.0000551896,0.001434716,0.9877723,0.0001290954,0.004939951,0.000006905418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875531,0.001665095,0.004919342,0.0002379466,0.0001553589,0.0000886236,0.0008377581,0.0001264428,0.004416229],"genre_scores_gemma":[0.9936586,0.0005881953,0.001655114,0.00006851069,0.00002802878,0.00004582392,0.0006954214,0.00001617925,0.003244037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929601,"threshold_uncertainty_score":0.006455183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07500050226641847,"score_gpt":0.3395248832572056,"score_spread":0.2645243809907871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}