{"id":"W3082090251","doi":"10.1093/jnci/djaa132","title":"Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institutes of Health; Prostate Cancer UK; National Cancer Institute; National Institute for Health and Care Research","keywords":"PALB2; Allele; Odds ratio; Prostate cancer; Germline; Genetics; Gene; Biology; DNA repair; Confidence interval; Cancer; Internal medicine; Oncology; Cancer research; Germline mutation; Medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184074,0.0001564348,0.000312187,0.000128898,0.0001173483,0.00002471774,0.000137636,0.00005214708,0.00004032271],"category_scores_gemma":[0.0001782678,0.00008443354,0.00009269763,0.0004198564,0.0002237402,0.0003291005,0.00006744411,0.0004020588,9.321704e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000945758,"about_ca_system_score_gemma":0.002850509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840402,"about_ca_topic_score_gemma":0.0002444732,"domain_scores_codex":[0.9982878,0.00004444383,0.0003614684,0.0001954012,0.0009016843,0.0002092125],"domain_scores_gemma":[0.9983158,0.00004048408,0.0005446332,0.00006748615,0.000852938,0.000178679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02071753,0.0003364379,0.8048876,0.00133953,0.003202847,0.004373306,0.01296523,0.03085297,0.06600415,0.0004205582,0.02524924,0.0296506],"study_design_scores_gemma":[0.06880143,0.004177198,0.5956159,0.02130406,0.001810845,0.004531133,0.00239371,0.01723545,0.1683371,0.001542653,0.1125329,0.001717571],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522319,0.0165791,0.000006362021,0.02960407,0.0002706044,0.0005245361,0.00009592856,0.00001363392,0.0006738457],"genre_scores_gemma":[0.9868483,0.008666132,0.0004490118,0.002035909,0.001197937,0.00006936971,0.000006446443,0.00002177658,0.0007051216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2092717,"threshold_uncertainty_score":0.505668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06278076299310154,"score_gpt":0.3563064826831872,"score_spread":0.2935257196900857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}