{"id":"W3082090251","doi":"10.1093/jnci/djaa132","title":"Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institutes of Health; Prostate Cancer UK; National Cancer Institute; National Institute for Health and Care Research","keywords":"PALB2; Allele; Odds ratio; Prostate cancer; Germline; Genetics; Gene; Biology; DNA repair; Confidence interval; Cancer; Internal medicine; Oncology; Cancer research; Germline mutation; Medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000702561,0.0003927602,0.0003539724,0.0008631545,0.0006647938,0.0005770664,0.0003354544,0.0003855985,0.001362384],"category_scores_gemma":[0.00211837,0.0005017187,0.0003262167,0.0008672804,0.0005204969,0.0002358802,0.0005594656,0.0002673174,0.0001485005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639448,"about_ca_system_score_gemma":0.0001903231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008835228,"about_ca_topic_score_gemma":0.00807339,"domain_scores_codex":[0.9992231,0.0001732435,0.0000784712,0.0002983886,0.0001370224,0.00008972381],"domain_scores_gemma":[0.9991397,0.00023051,0.0003334186,0.0001025926,0.00006861924,0.0001252062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008572073,0.00002398142,0.9972537,0.00001170462,0.00005262203,0.0003455162,0.000327067,0.00004222412,0.0008085068,0.00002623871,0.0000439135,0.0009787692],"study_design_scores_gemma":[0.00001640796,0.0002048873,0.9962099,0.000008614453,0.0001004675,0.002112575,0.0003730389,0.0001582084,0.0003900201,0.00003344125,0.0003875554,0.000005018688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995234,0.0001606672,0.00008021964,0.000004761374,0.000001326336,0.000006048188,0.0001077276,0.000002042079,0.0001139211],"genre_scores_gemma":[0.99967,0.00006062807,0.00006158047,0.00001077518,0.000002928692,0.000003988092,0.0001193308,0.000001138783,0.00006958669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008835228,"threshold_uncertainty_score":0.01756757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06278076299310154,"score_gpt":0.3563064826831872,"score_spread":0.2935257196900857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}