{"id":"W3082159235","doi":"10.1158/2326-6074.tumimm18-b60","title":"Abstract B60: Functional genomic landscape of T-cell mediated cytotoxicity","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Biology; CTL*; Cancer immunotherapy; Immunotherapy; CRISPR; Cytotoxic T cell; Computational biology; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001663362,0.0003386698,0.000395284,0.0005646421,0.0002131861,0.0006872094,0.0002976748,0.0004754512,0.004903209],"category_scores_gemma":[0.0002447832,0.0001845796,0.0003311984,0.0004743896,0.0003273423,0.0001677864,0.0004941612,0.0005287282,0.001864513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003407765,"about_ca_system_score_gemma":0.000257793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006715162,"about_ca_topic_score_gemma":0.0008237031,"domain_scores_codex":[0.9997159,0.00002153513,0.00001423413,0.0001060364,0.00008943276,0.00005298185],"domain_scores_gemma":[0.9998268,0.00002729685,0.00004982881,0.00001770745,0.00002211576,0.0000562122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001195098,0.000009861099,0.0008064803,0.00003840623,0.000008026564,0.0000533087,0.00001122532,0.0002550014,0.9952627,0.000322237,0.0001431382,0.002969969],"study_design_scores_gemma":[0.0001169243,0.001123896,0.0890791,0.00009720525,0.0001357329,0.001811114,0.0001912489,0.007545695,0.8653271,0.003500048,0.03101101,0.00006095876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709296,0.003187138,0.01270014,0.0003012841,0.00006000222,0.00003887454,0.005693477,0.000657589,0.006432034],"genre_scores_gemma":[0.9831042,0.001136971,0.004835785,0.000234702,0.0000155882,0.00004052807,0.006214893,0.0001843536,0.004233017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004903209,"threshold_uncertainty_score":0.01640284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034502505728455,"score_gpt":0.3694555785910577,"score_spread":0.2660053280182122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}