{"id":"W3082159235","doi":"10.1158/2326-6074.tumimm18-b60","title":"Abstract B60: Functional genomic landscape of T-cell mediated cytotoxicity","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Biology; CTL*; Cancer immunotherapy; Immunotherapy; CRISPR; Cytotoxic T cell; Computational biology; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008751457,0.0001625846,0.0004612372,0.0003236473,0.000122063,0.00001528258,0.0003547478,0.0002689367,0.03993301],"category_scores_gemma":[0.0003622018,0.0001471861,0.0001377022,0.0008296846,0.000692728,0.00005819639,0.0002465686,0.001564583,0.0006415206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460751,"about_ca_system_score_gemma":0.001300392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002980558,"about_ca_topic_score_gemma":0.00002362678,"domain_scores_codex":[0.9974234,0.0002165676,0.0003793814,0.0004679372,0.0007982249,0.0007145343],"domain_scores_gemma":[0.9980285,0.0005264223,0.000075768,0.0004403369,0.0006674296,0.0002615993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004118865,0.0001743234,0.02253158,0.0001774241,0.0002722804,0.00005665271,0.0003405338,0.00001198814,0.9631587,0.00002604285,0.007187906,0.001943679],"study_design_scores_gemma":[0.005767409,0.001245196,0.3936466,0.00005760566,0.00002764883,0.00002762957,0.0004822524,0.0002827285,0.57767,0.00005804339,0.02053558,0.0001992692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730765,0.00560223,0.00001137941,0.004786779,0.0001271576,0.0006271286,0.00005991843,0.00005513957,0.01565379],"genre_scores_gemma":[0.9935089,0.002418227,0.00003343889,0.0003102792,0.0003844514,0.0001215048,0.00008066943,0.00004669592,0.003095823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3854887,"threshold_uncertainty_score":0.9609446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034502505728455,"score_gpt":0.3694555785910577,"score_spread":0.2660053280182122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}